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The treatment of chronic myeloid leukemia has changed dramatically in the
last few years. Stem-cell transplantation and the use of interferon alfa had
already offered the possibility of complete and durable cytogenetic responses,
improving the survival over that expected with conventional chemotherapy. The
introduction of imatinib mesylate has started the era of molecular therapy with
remarkable results including complete cytogenetic responses in up to 90% of
patients and major molecular responses in most.
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