GREAT answer to this question, Ho. Thanks a lot. How are you doing, btw? You had said that IM caused you a lot of fatigue and brain "fuzziness;" has this improved at all?
Best, Richard R > Date: Mon, 17 Jan 2005 21:38:34 -0800 (PST) > From: Ho-Leung Ng <[EMAIL PROTECTED]> > Subject: Re: IM, feeling cold - Ho > > Hello Cheryl-Anne, > > It is possible that the thyroid is working fine > but that the response to thyroid hormone is awry. This > is analogous to type 2 diabetes where insulin is > produced but the body responds poorly to it. However, > when this happens to cause hypothyroidism, it is > usually a general resistance throughout the body, > including the pituitary gland which controls the > thyroid by secreting TSH (thyroid stimulating > hormone). If the pituitary is also resistant, the > normal negative feedback mechanism that maintains > homeostasis/equilibrium is broken, so the pituitary > secretes extra TSH which causes the thyroid to produce > extra thyroid hormone. Ironically, this type of > functional hypothyroidism is associated with higher > levels of TSH and thyroid hormone. > > However, if the resistance occurs only in certain > cell/tissue types but NOT the pituitary - TSH and > thyroid hormones will remain normal. I performed a > superficial PubMed search and learned that this is > called "selective peripheral resistance to thyroid > hormone" and has only been observed in one patient. > However, Gleevec has such a specific mechanism of > action that it would not surprise me that it could > cause such a specific physiological failure by > blocking a kinase involved with responding to the > thyroid hormone signal. > > Note that this is primarily speculation on my > part, but it is speculation that is testable in a > research laboratory. > > I apologize in advance for being long winded. > > > ho ------------------------ Yahoo! Groups Sponsor --------------------~--> Give the gift of life to a sick child. Support St. Jude Children's Research Hospital's 'Thanks & Giving.' http://us.click.yahoo.com/3iazvD/6WnJAA/xGEGAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
