Hi
I am 25 and live in Scotland, I was diagnosed with CML in March 04, I was at diagnosis I had a 54.5% Ph+ after 8 months on Glivec 400mg I now am 0.016% Ph+ so responding well. Initially I did not really want to become involved in the CML Community, however the last few months I have been tracking discussions and found I want to know more about this condition. At diagnosis I was given a booklet five or six years out of date which painted a very bleak picture, this has changed so much in a few short years, if this rate of development continues I for one am very hopeful that a complete cure is just a few years away, I now find myself worrying about long term side affects of relatively untested drugs instead of the thought of not reaching my 30th birthday. I may have the opportunity to participate in a Phase 1 Clinical Trial which will involve 45 people. The trial is for people responding well to Glivec. There will be three parts to this trial and I wouldn't be able to choose which arm I would be on. � 15 people will take Glivec as normal � 15 people will take a pulsed dose of Glivec 3 weeks on one week off � 15 people will take a pulsed dose of Glivec 3 weeks on one week off, injecting growth factor in the week off of Glivec. Pulsing Glivec Whilst off Glivec sleeping Leukaemia cells have time to wake up, divide once active Glivec should be able to shut them down. Growth Factor The growth factor will be applied in the week off Glivec this should force any sleeping cells to wake up, divide, again once the cell has become active Glivec should be able to shut it down. The theory Allowing or forcing the leukaemia to grow then in turn makes it an easy target for Glivec to shut down, this is hoped to turn low PCR results to negative PCR results. I will not be eligible for this trial until I have been stable for six months that will be at 11 months on Glivec. So I may be too late to participate in this trial. This is a Phase 1 trial so just about completely untested though I feel very positive about it, I was wondering if anyone had experience of using growth factor (I think it's called GCFS) in combination with Glivec possibly for Stem Cell Collection, or pulsing of doses of Glivec? Thanks David ------------------------ Yahoo! Groups Sponsor --------------------~--> Help save the life of a child. Support St. Jude Children's Research Hospital's 'Thanks & Giving.' http://us.click.yahoo.com/0iazvD/5WnJAA/xGEGAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
