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The Bcr-Abl tyrosine kinase oncogene causes chronic myelogenous leukemia
(CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia
(ALL). We describe a novel selective inhibitor of Bcr-Abl, AMN107 (IC50 <30
nM), which is significantly more potent than imatinib, and active against a
number of imatinib-resistant Bcr-Abl mutants.
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