Sheila,
My name is Pat dxd 11/04 WBC 330,000, platelets 1,500,000...on Gleevec and Hydroxyurea for 10 days to get WBC under 200,000 went home, had fevers for a week, went back into hospital for 5 days and went home again with counts still going down.
 
WBC went to normal up until April '05 and from then on went up and down, but platelets never went down to normal always above a million.  In April '06 we upped the dosage to 600mg and still same WBC ran about 30,000 and platelets always at 1 million 700,00 to 1 million 900,000, sometime taking Hydroxyurea  along with Gleevec to get them all down and then off the hydrea..
    
April this year Dr. sent me to Tucson to talk to experts there and gave me options.  I decided to wait for new AMN107 to come out this year, Sprycel became available sooner (7/1).
 
I took Sprycel for 15 days and all counts went right away to normal, went off for four days and counts still came down a tad, took one pill (normal dose = 1 pill 2xdaily) for 2 days last Tuesday and Wednesday, stopped taking last Thursday, had labs done Monday and counts are a tad under normal.
 
It is a great chemo as far as I am concerned, just need to find a dose that is consistent for me.  I had become resistant to the Gleevec.
 
Pat

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