Monosomy 7 is one of the most common secondary chromosome issues for those with CML, and it is normally transient (comes and goes). If the Monosomy 7 is confirmed by re-testing, an important question to ask the Onc is whether the Monosomy 7 is showing up in the Ph+ (leukemic) cells or in the Ph- (non-leukemic) cells. If in the Ph- cells, it is not necessarily a significant issue, and could possibly go away by itself over time. But if the Monosomy 7 is in the Ph+ cells, then it could possibly be a sign of disease progression. But since this issue is not well understood, close monitoring for any signs of progression or Gleevec resistance is important.
http://online.haematologica.org/EHA13/browserecord.php?-action=browse&-recid=2648 It is unknown whether this is caused by Gleevec. There is a clinical trial starting that is trying to figure this out by testing non-CML users of Gleevec (those with an intestinal tumor called GIST) to see if GIST patients develop Monosomy 7 and other abnormalities. If they do, then that would show that Gleevec is the cause, not the CML. http://clinicaltrials.gov/ct2/show/NCT00461929 --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
