Possible, and easy. I actually have an autogenerated wrapper for all of LAPACK using CFFI: http://middleangle.com/rif/derifatives/article/21/cl-blapack-alpha-release
I have not personally run this on cmucl (only sbcl), but it should be relatively straightforward. There is also MATLISP, which is a higher-level and therefore more pleasant interface, although I don't know if it includes the functionality you wnat. I have added new LAPACK functions to MATLISP in the past, but it's not an enjoyable activity. rif
