This worked for me. I had a unused Fiber NIC still installed and removed it.
FYI: NIC Had LSI Chip (L2A1157) and I have a Nvidia Quadro FX 4800/PCIe/SSE2 
graphics card installed.

Seems to be some type of Hardware & IRQ issue.
Problem has been gone for last 2 days.
Previously this issue would appear within half hour or so after logging in.

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https://bugs.launchpad.net/bugs/996008

Title:
  GUI slows down significantly after random period of time.

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