I realize that I left out a key detail, and had a typo on my last post. I am running Coot 0.5 on OSX (intel). The error message I see when I try to refine a monomer I generate with the CCP4 monomer library sketcher that there are NO restraints found for the ligand (despite the fact that I read in the mon_lib.cif file before reading in the coordinates for the monomer(s) in question). Thanks!
Les
