*       Why not rename chains and if necessary renumber

 

Sure, that is how I had to do it. But with many chain fragments and residues in 
the high thousands and 

medium to low resolution this becomes cumbersome. Many domain/motif/helix 
connections are initially exploratory and 

determine the residue numbers/sequence based on side chain fit. Then everything 
changes 

again when you correct. 

 

I don’t think anything is unrealistic about the link per se – the chain 
assignment or residue numbers are unrealistic 

in the beginning.

 

Best, BR

 

From: Mailing list for users of COOT Crystallographic Software 
<[email protected]> On Behalf Of Eleanor Dodson
Sent: Wednesday, March 31, 2021 23:43
To: [email protected]
Subject: Re: Link residues in different chains

 

Why not rename chains and if necessary renumber residues to make a sensible 
single chain? Very easy with the edit options and much simpler than creating an 
unrealistic link?? 

I find myself going that often after an build molecule run. 

Eleanor 

 

On Thu, 1 Apr 2021 at 00:40, Paul Emsley <[email protected] 
<mailto:[email protected]> > wrote:

On Wed, 2021-03-31 at 16:34 -0700, Kevin Jude wrote:
> Just want to note that it's not that esoteric - it's not uncommon to
> find (or engineer) disulfide bonds between chains, eg 6WDQ, 6BJ8, and
> others that I have worked on. Being able to RSR those links would be
> quite useful!
> 
> --
> Kevin Jude, PhD (he/him/his)
> Structural Biology Research Specialist, Garcia Lab
> Howard Hughes Medical Institute
> Stanford University School of Medicine
> Beckman B177, 279 Campus Drive, Stanford CA 94305
> Phone: (650) 723-6431
> 
> 
> On Wed, Mar 31, 2021 at 3:04 PM Paul Emsley <
> [email protected] <mailto:[email protected]> > wrote:
> > On 31/03/2021 22:08, Bernhard Rupp wrote:
> > > 
> > > I spectacularly fail trying to link for real space refine 2
> > different chains with the modelling/make link 
> > > command.
> > 
> > The bonding in Coot's RSR only works within the chain - including
> > links. (You can make links between chains, 
> > but RSR won't use them.)
> > 
> > > How can I do that short of renaming my chains?
> > 
> > If I understand what you are trying to do (sounds a bit esoteric)
> > then I don't think that there is a way.
> > 
> > Paul.
> > 

OK, interesting. I've made a note.

Paul.

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