-Caveat Lector-

A deadly Malaysian virus has U.S. scientists scrambling for answers

Copyright © 1999 Nando Media
Copyright © 1999 Associated Press

By PATRICIA J. MAYS

ATLANTA (May 3, 1999 2:09 p.m. EDT http://www.nandotimes.com) - In a
quarantined laboratory, U.S. scientists outfitted in plastic
biohazard spacesuits and breathing through air tubes are investigating a
deadly virus that is wreaking havoc on the other side of the
world.

The mysterious microscopic enemy has killed more than 100 people in
Malaysia in seven months, and scientists are baffled about its
origin and mode of transmission.

"Every couple of years something like this comes along," says Dr. C.J.
Peters, head of the special pathogens branch at the Centers for
Disease Control and Prevention. "We don't know how this stuff spreads,
how far it's going to go. We really don't know what's at the end of
the tunnel."

The rare form of viral encephalitis, which spread from pigs to humans, first
surfaced last year near the northern city of Ipoh. It has since
sickened more than 250 Malaysians, mostly pig farmers. Many of their
herds also fell ill, and some pigs died. A similar illness afflicted 11
slaughterhouse workers in Singapore, one fatally, who butchered pigs
imported from Malaysia.

Soldiers have killed almost 1 million pigs and some stray dogs to try to
curb the virus. On Monday, pet owners in Malaysia's high-risk
areas were told to get their animals checked immediately after new tests
confirmed house pets could transmit the disease to humans.

Medical authorities named the new virus Nipah, after the village where it
was first isolated.

As remote as the Nipah virus may seem, controlling and understanding it
are a concern of epidemiologists around the globe because of
fear it could spread quickly.

"In today's world, it's not unrealistic to think of the possibility that someone
could get on a plane and land in San Francisco with it," says
Dr. Duane Gubler, director of the CDC's Division of Vector-Borne
Infectious Diseases at Fort Collins, Colo.

For months, Malaysian health officials were certain the killer was Japanese
encephalitis, a mosquito-borne virus common to the area.
The two pathogens cause similar symptoms - high fever, aches, eventual
coma and, often, death.

But most people in the region had been vaccinated for JE as children.
Additionally, it doesn't usually kill adult pigs.

The government declared a state of emergency in three Malaysian states
and launched fogging and vaccination campaigns, to no avail.
The Nipah virus raged on. And despite no proof that Nipah can infect
people who eat or handle pork, the epidemic has wreaked havoc on
Malaysia's nearly $400 million pork industry.

On March 7, baffled Malaysian researchers sought help from their
counterparts at Gubler's CDC office in Fort Collins.

"It was quite fortuitous that when I sent him an offer to help, he was in the
process of sending a note to the CDC asking for help," Gubler
says.

The following Saturday morning, a Malaysian researcher arrived in Fort
Collins with slides of cells infected with the mysterious virus. The
researchers worked through the weekend, screening the sample against
dozens of known viruses. All were negative.

When they tried to isolate Nipah, it formed giant cells with multiple nuclei -
epidemiological patterns not at all like JE. By Sunday, a red
flag had gone up: The Nipah virus fit in none of the three virus families
studied at Fort Collins and was actually a previously unknown
paramyxovirus. This family includes measles and mumps, but one of the
last new paramyxoviruses discovered was the especially virulent
Hendra virus.

"That was when we packed it up and sent it to Atlanta," Gubler says.

The samples were taken to the CDC's Level 4 biocontainment lab, which
houses deadly microbes that have no vaccine or cure, such as
the Ebola virus that killed 245 Zaireans in 1995.

The CDC's medical detectives quickly identified the culprit as related to but
far deadlier than the very rare Hendra virus. Hendra was first
detected in 1994 in Australia, where it killed 15 racehorses and two
trainers.

But they know little else.

"That indicated right away that this was something big. We knew it was a
new virus and we knew it was related to a virus that kills
people," Peters says. "We're not talking about an outbreak of colds that's
going to run through and everybody's going to get over it."

In late March, a team of eight CDC epidemiologists and two Australian
researchers packed questionnaires, protective gear, needles and
vials and headed for Malaysia.

Wearing gloves, rubber coveralls, boots and battery-operated respirators,
the disease detectives began combing through animal feed
and trapping rodents. They have spent weeks tramping through pig pens
and farming villages in the worst-hit areas. They are interviewing
victims and their families and friends: What did they eat? What did they
drink? Where did they go? What did they do? It's all to form a
hypothesis about how the virus is transmitted.

Blood samples have been taken from birds, turkeys, goats, horses, cattle
and wild animals. With the Hendra virus, the culprits were fruit
bats.

"We have no idea what the natural reservoir of this virus is," Gubler says.

The CDC's next step is to try to develop a genetically engineered vaccine
using mice, rats and guinea pigs.

But Peters hopes the vaccine isn't needed. Killing hundreds of thousands
of pigs seems to have helped - as of last week, the number of
new cases appeared to be declining, and the disease may ease naturally.

"If we're lucky," Peters says, "in two or three months the outbreak will come
under control and we'll never have to make a vaccine."

------------------------------------------------------------------------
Steve Wingate

California Director
SKYWATCH INTERNATIONAL

ANOMALOUS IMAGES AND UFO FILES
http://www.anomalous-images.com

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