-Caveat Lector-
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United States Patent 4,641,633
Delgado February 10, 1987
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Electronic system for the activation, inhibition and/or
modification of the development and functioning of cells, organs
and organisms of living beings
Abstract
Instrumentation and methodology for the application of non-invasive
electromagnetic fields characterized by sharp, unidirectional
square waves with rising and falling times below 0.1 microseconds
and frequencies below 120 pulses per second. The waves are applied
through antennas which produce magnetic fields. The magnetic
fields are applied to living beings with the purpose of producing
predictable modifications of determined structures, functions and
manifestations.
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Inventors: Delgado; Jose M. R. (Caleruega 21, Madrid, ES)
Appl. No.: 726922
Filed: April 25, 1985
<snip>
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Claims
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1. An electromagnetic system for non-invasive modification of
living cells and organisms, comprising:
o electronic generator means for generating very stable,
unidirectional, symmetrical square waves, and including means
for adjusting the timing of said square waves to provide very
sharp square waves having rise times and fall times each of
less than 0.1 microsecond; and
o at least one antenna means for receiving said square waves and
producing magnetic fields which can be applied to the living
cells and organisms to modify their morphological and
functional characteristics without disturbance of the cellular
membrane protecting the cell and organism.
2. An electromagnetic system as in claim 1, wherein said electronic
generator means comprises means for producing a high frequency
component signal of between 10 Kilohertz and 100 Megahertz, said
high frequency signal being modulated by said square waves.
3. An electromagnetic system as in claim 1, wherein the frequency
of said square waves is less than 120 pulses per second.
4. An electromagnetic system as in claim 1, wherein said square
waves are grouped as repetitive pulse trains having repetition
rates between 10 milliseconds and 10 seconds, and the number of
pulses in each pulse train varies between two and one hundred.
5. An electromagnetic system as in claim 1, further comprising time
counter means coupled to said generator means for monitoring the
time and duration of application of the magnetic field.
6. An electromagnetic system as in claim 1, wherein said generator
means comprises a plurality of integrated circuit timing devices
for producing said square waves, and an integrated circuit logic
selection circuit for providing selection of said square waves in
a single, repetitive or grouped arrangement and for direct
application as well as a modulating application of said square
waves.
7. An electromagnetic system as in claim 1, and further comprising
a first power source for providing a first rectified power output
to said generator means, a second power source for providing a
second rectified power output, regulator means for controlling the
level of the second rectified power output, and a power driver
circuit receiving the output from said generator means and said
second rectified power output, the output from said power driver
circuit being applied to said at least one antenna means.
8. An electromagnetic system as in claim 1, wherein said antenna
means comprises two square antennas, and a continuous cylindrical
elastic material supporting said square antennas.
9. An electromagnetic system as in claim 1, wherein said antenna
means comprises a plastic housing having a central bore for
receiving a living organism, and a pair of square antennas embedded
in the plastic material of said housing in diametrically opposed
positions with respect to said central bore.
10. A method of non-invasive modification of living cells and
organisms, comprising applying an antenna non-invasively with
respect to the organism, applying to the antenna very stable,
unidirectional, symmetrical and very sharp electrical square waves
with rising and falling times each of less than 0.1 microsecond to
cause the antenna to produce a magnetic field which penetrates into
the organism without disturbing the cellular membrane of the
organism.
11. The method of claim 10, wherein the square waves applied to the
antenna modulate a high frequency signal of between 10 Kilohertz
and 100 Megahertz.
12. The method of claim 10, wherein the square waves have a
frequency less than 120 pulses per second.
13. The method of claim 10, wherein the square waves are grouped
as repetitive pulse trains having repetition rates between
10 milliseconds and 10 seconds, and the number of pulses in each
pulse train varies between two and one hundred.
14. An electromagnetic system for non-invasive bone growth
stimulation, comprising:
o electronic generator means for generating very stable,
unidirectional, symmetrical square waves, and including means
for adjusting the timing of said square waves to provide very
sharp square waves having rise times each and fall times of
less than 0.1 microsecond; and
o at least one antenna means for receiving said square waves and
producing magnetic fields which can be applied to living bone
to modify its morphological and functional characteristics
without disturbance of the bone structure.
15. An electromagnetic bone growth stimulation system as in claim
14, wherein said electronic generator means comprises means for
producing a high frequency component signal of between 10 Kilohertz
and 100 Megahertz, said high frequency signal being modulated by
said square waves.
16. An electromagnetic bone growth stimulation system as in claim
14, wherein the frequency of said square waves is less than 120
pulses per second.
17. An electromagnetic bone growth stimulation system as in claim
14, wherein said square waves are grouped as repetitive pulse
trains having repetition rates between 10 milliseconds and 10
seconds, and the number of pulses in each pulse train varies
between two and one hundred.
18. A method of non-invasive bone growth stimulation, comprising
applying an antenna non-invasively with respect to living bone, and
applying to the antenna very stable, unidirectional, symmetrical
and very sharp electrical square waves with rise times and fall
times each of less than 0.1 microsecond to cause the antenna to
produce a magnetic field which penetrates into the bone without
disturbing the bone structure.
19. The bone growth stimulation method of claim 18, wherein the
square waves applied to the antenna modulate a high frequency
signal of between 10 Kilohertz and 100 Megahertz.
20. The bone growth stimulation method of claim 18, wherein the
square waves have a frequency less than 120 pulses per second.
21. The bone growth stimulation method of claim 18, wherein the
square waves are grouped as repetitive pulse trains having
repetition rates between 10 milliseconds and 10 seconds, and the
number of pulses in each pulse train varies between two and one
hundred.
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Description
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The present invention concerns an electronic system for the
activation, inhibition, and/or modification of the development and
functioning of cells, organs, and organisms of living beings,
applicable from unicellular organisms up to human beings.
The above mentioned system is based on the generation and
application of local electrical fields, induced remotely by
electromagnetic means, with biological effects which depend on
the programming and on preselected parametric characteristics.
Since 1947 the inventor and some of his collaborators have
performed and published a large series of experiments to
investigate morphological, physiological, and pathological effects
produced in cells, organs, and organisms of different animal
species from bacteria and insects up to humans, produced by
electrical stimulae of special characteristics, applied directly or
by electromagnetic induction. Results of these investigations have
been published successively through the years to describe each new
discovery.
The following provides a list of some of these investigations
published by the inventor:
Reference 1: Delgado, J. M. R. and R. B. Livingston. SOME
RESPIRATORY, VASCULAR AND THERMAL RESPONSES TO STIMULATION OF
ORBITAL SURFACE OF FRONTAL LOBE. J. Neurophysiol., 11:39-55, 1948.
Reference 2: Mihailovic, L. and J. M. R. Delgado. ELECTRICAL
STIMULATION OF MONKEY BRAIN WITH VARIOUS FREQUENCIES AND PULSE
DURATIONS. J. Neurophysiol., 19:21-36, 1956.
Reference 3: Delgado, J. M. R. MULTICHANNEL TRANSDERMAL STIMULATION
OF THE BRAIN. Tech. Doc. Rep. #ARL-TR-70-1. Holloman AFB, New
Mexico, 24pp. 1970.
Reference 4: Delgado, J. M. R. PHYSICAL CONTROL OF THE MIND: TOWARD
A PSYCHOCIVILIZED SOCIETY. Vol. XLI, World Perspectives Series, R.
N. Anshen (Ed.), New York: Harper & Row, 280pp., 1969.
Reference 5: Delgado, J. M. R. RADIOCOMMUNICATION WITH THE BRAIN.
(10p. brochure for exhibit). Gold Medal Award, Amer, Psychiat.
Assoc. Meeting, May 3-6, Washington, D.C., 1971.
Reference 6: Delgado, J. M. R. COMMUNICATION WITH THE CONSCIOUS
BRAIN BY MEANS OF ELECTRICAL AND CHEMICAL PROBES. Pp. 25-40 in:
"Biological Diagnosis of Brain Disorders". Proc. V. int. Conf. on
the Future of Brain Sciences. New York: Spectrum-Wiley, 1973.
Reference 7: Delgado, J. M. R., V. Lipponen, G. Weiss, F. del Pozo,
J. L. Monteagudo, and R. McMahon. TWO WAY TRANSDERMAL COMMUNICATION
WITH THE BRAIN. Amer. Psychologist, 30:265-273, 1975.
Reference 8: Delgado, J. M. R. TRANSDERMAN COMMUNICATION WITH THE
BRAIN IN ANIMALS AND MAN. Invited lecture, XXVI int. Congr.
physiol. Sci., New Delhi, October, 1974. Proc. int. Union physiol.
Sci. XI: 27, 1974.
Reference 9: Delgado, J. M. R. NEW ORIENTATIONS IN BRAIN
STIMULATION IN MAN. Pp. 481-503 in: "Brain-Stimulation Reward",
Proc. 1st int. Conf., A. Wauquier and E. T. Rolls (Eds.),
Amsterdam North Holland Publ. Co., 622 pp., 1976.
Reference 10: Delgado, J. M. R. INSTRUMENTATION, WORKING
HYPOTHESES, AND CLINICAL ASPECTS OF NEUROSTIMULATION. Appl.
Neurophysiol., 40:88-110, 1977/78.
Reference 11: Delgado, J. M. R., J. L. Monteagudo, M. Garcia Gracia
and J. Leal. TERATOGENIC EFFECTS OF WEAK MAGNETIC FIELDS. IRCS med.
Sci., 9:392, 1981.
Reference 12: Delgado, J. M. R., J. Leal, J. L. Monteagudo and M.
Garcia Gracia. EMBRYOLOGICAL CHANGES INDUCED BY WEAK, EXTREMELY LOW
FREQUENCY ELECTROMAGNETIC FIELDS. J. Anat., 134:533-551, 1982.
Reference 13: Delgado, J. M. R., J. Leal, A. Parreno, M. Garcia
Gracia and J. L. Monteagudo. DIOLOGICAL EFFECTS OF WEAK
ELECTROMAGNETIC FIELDS. En Proc. 5th Europ. Neurosci. Conf. Liege,
September, 1981.
Reference 14: Monteagudo, J. L., M. Garcia Gracia, J. Leal, C.
Hernandez-Ros, E. Ramirez, J. Ortega Klein, J. Palacios Carvajal y
J. M. R. Delgado. APLICACION BIOMECANICA DE ESTIMULOS MAGNETICOS.
Abstr. en Proc. IV Simp. Soc. iber. Biomecanica, Valencia,
November, 1981.
Reference 15: Garcia Gracia, M., J. L. Monteagudo, E. Ramirez and
J. M. R. Delgado. ELECTROMAGNETIC MODIFICATIONS OF THE BRAIN. In
Proc. 1st World Congr. IBRO, Lausanne, April, 1982.
Reference 16: Leal, J., A. Ubeda, A. Trillo, J. L. Monteagudo and
J. M. R. Delgado. MODIFICATION OF EMBRYOGENESIS BY MAGNETIC FIELDS.
In Proc. 1st World Congr. IBRO, Lausanne, April, 1982.
Reference 17: Ubeda, A., M. A. Jimenez, M. A. Trillo, J. Leal,
and J. M. R. Delgado. FAVORABLE AND TERATOGENIC EFFECTS OF
ELECTROMAGNETIC FIELDS ON CHICK EMBRYOGENESIS. In Proc. EDBO Conf.,
Strasburg, June, 1982.
Reference 18: Delgado, J. M. R. ELECTROMAGNETIC EFFECTS: FROM
INSECTS TO HUMANS. In Proc. Symposium on "Biomagnetism in
Psychophysiology" 1st. Int. Conf. on Psychophysiology, Montreal,
August, 1982.
Reference 19: Ramirez, E., J. L. Monteagudo, M. Garcia Gracia and
J. M. R. Delgado. ELECTROMAGNETIC EFFECTS IN DROSOPHILA. In Proc.
6th Europ. Neurosci. Congr., Torremolinos, September, 1982.
Reference 20: Paino, C. L. and J. M. R. Delgado. RUNWAY PERFORMANCE
MODIFIED BY ELECTROMAGNETIC FIELDS. In Proc. 6th Europ. Neurosci.
Congr., Torremolinos, September, 1982.
One of the objectives of all these studies has been the activation,
inhibition, and modification of cells and organisms by means of
their electrical stimulation which may be programmed and applied by
remote control through the intact skin in such a way that different
effects have been obtained by choosing different, specific
electrical parameters.
The importance of codification of signals and parameters of
electrical currents to obtain specific biological effects was
studied and demonstrated by the inventor and others in the above
identified References 1 and 2. Many of these findings are
summarized in the above Reference 4. In the recent published
investigations referred to above References 12 and 18, there has
been shown that some parameters of electromagnetic waves may have
detrimental teratogenic effects. These references show the
importance of the shape of the magnetic waves in producing
beneficial results. It is shown in these references, that it is
essential to have suitable experimental knowledge about which
parameters have beneficial, neutral or detrimental effects.
All this previous research led to the development and construction
of the system which is the object of the invention, constituting a
new system in its electronics, biological effects, and possible
scientific and therapeutic applications.
The system, developed according to the invention, consists of a
generator of signals produced electronically and one or several
antennas which radiate electromagnetic energy over a tissue or
biological organism.
The use of electromagnetic coils applied to the skin for
transdermal stimulation of tissues, and retaining methods for this
purpose, are described in great detail in the above identified
references. These include studies performed on monkeys,
chimpanzees, and in human patients. These are described in the
above identified References 4, 3, 5, 7, 9 and 9.
It should be emphasized that the use of inductive coils to provide
electrical current is not new. The use of two coils separated by a
distance smaller than their diameter constitutes the configuration
known as "Helmholz coils", honoring the memory of the illustrious
German physics professor, H. L. F. von Helmholtz (1821-1894) who
studied the properties of these coils which from his time have been
described in many textbooks on electricity.
The following is a detailed description of the system, illustrated
with drawings and presented as orientation, not as limitation of
the system.
<snip>
In summary, by means of the described system and based on our
experience accumulated since 1947, we can influence cells, organs,
and organisms of different species, and these applications include
scientific investigations and therapeutic use, based as already
explained on the production of local electrical fields induced by
externally applied electromagnetic fields of specific
characteristics.
The inventor reserves the rights to introduce in the present
invention any improvements which could be legally acceptable.
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