-Caveat Lector-

"To create animal clones, scientists frequently made hundreds of failed
attempts to develop viable embryos. Medical ethicists have posed the
possibility of cruel failures in human cloning, where genetic abnormalities
result in grotesque foetuses unable to survive outside the womb. "

Human clone `only 18 months away'
By ANDREW STERN in Chicago
30jan01

REPRODUCTIVE experts in the United States are at loggerheads after
one group claimed it would clone humans within 18 months.

A separate group, which refused to be identified, said such a move was
technically feasible but probably would produce many stillborn or
genetically diseased embryos.

The group planning the cloning said it would provide children to infertile
couples.

A viable embryo, probably using stem cells or other cells taken from the
man, could be available for implantation in the woman's uterus within 18
months, said Dr Panayiotis Zavos, of The Andrology Institute of America
and the Kentucky Centre for Reproductive Medicine and Invitro Fertilisation
in Lexington, Kentucky.

"This is going to be the first serious effort," Dr Zavos said.

"I do know various individual groups that are acting on their own, but they
lack the support."

Scientists have cloned sheep, beginning with "Dolly" in Scotland in 1997,
as well as mice and cows, but any suggestion of cloning humans has been
met by outrage within the scientific community and in political and religious
circles.

"As revolutionary as it may sound, as fictional as it may sound, it will be
done," Dr Zavos said.

"It's a genie that is out of the bottle and will be controlled." He said 10
infertile couples had volunteered to participate.

One US pair cannot conceive because the man's testicles were severed in
an accident, he said.

The consortium would operate in a Mediterranean country.

Dr Zavos said his group would hold a conference in Rome in March,
inviting a cardinal from the Vatican, which opposes human cloning.

The scientists plan to use regular cells or undifferentiated stem cells from
the husband and insert them into an ovacyte, a woman's egg stripped of its
genetic material.

The cell would be stimulated to divide and create an embryo equipped with
all the specialty cells that make up a copy of the man, and then implanted in
the wife's uterus. The wives could also be the person cloned, depending on
the couple's choice, he said.

"We have a great deal of knowledge. We can grade embryos, we can do
genetic screening, we can do quality control," Dr Zavos said.

"It's not the easiest thing. The stability of the genetic information is what's
important. We're cloning a human being now, we're not trying to create a
Dolly. You don't want to create a monster," he said.

To create animal clones, scientists frequently made hundreds of failed
attempts to develop viable embryos. Medical ethicists have posed the
possibility of cruel failures in human cloning, where genetic abnormalities
result in grotesque foetuses unable to survive outside the womb.


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