10/17/2001 - Updated 11:14 PM ET



U.S. requesting 300M smallpox vaccines

By Julie Appleby, USA TODAY

The U.S. government wants to order 300 million doses of a new
smallpox vaccine, more than seven times the number originally
requested, Health and Human Services Secretary Tommy Thompson said
Wednesday.

Thompson has asked British firm Acambis to produce 54 million doses,
up from its contract for 40 million, and is negotiating with other
drug manufacturers, including giants Baxter and Merck.

Officials at Baxter and Merck said they are providing scientific and
technical assistance, although neither company is working to produce
a vaccine.

The surprise announcement came during a press conference at which
Thompson and other health officials repeatedly asserted that the USA
has plenty of antibiotics with which to fight anthrax.

Earlier, Thompson asked Congress for $1.5 billion for bioterrorism
efforts, including $509 million to speed development of a smallpox
vaccine and $643 million to expand an antibiotic stockpile.

Although 300 million doses would be enough to vaccinate the entire
U.S. population, Thompson did not call for routine vaccination.

"Right now all we're doing is preparing the supplemental
appropriation to purchase the 300 million doses," Thompson said.

The secretary also said pharmaceutical industry leaders have "assured
us they would work to meet the demand the government might have for
medicines in an emergency." Bayer has already tripled production of
its anthrax treatment Cipro, expecting to make 200 million tablets
during the next 60 days.

Acambis was scheduled to deliver the smallpox vaccine in 2004.
Thompson says it will be ready next year, although some vaccine
experts question whether it can be done that fast.

Routine smallpox vaccination ended in 1972, but the Centers for
Disease Control and Prevention retains a stock of 15.4 million doses
of vaccine from that era. Tests are under way to see if the old
stocks of vaccine can be diluted to increase the supply to about 77
million doses.

Contributing: Anita Manning and Rita Rubin.





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