-Caveat Lector-

http://www.boston.com/dailyglobe2/325/metro/Harvard_professor_missingP.shtml

Harvard professor missing

By Douglas Belkin, Globe Staff and Jenny Jiang Globe Correspondent,
11/21/2001

A world-renowned Harvard scientist and expert in highly contagious and deadly
viruses mysteriously disappeared in Tennessee early last Friday, leaving a
rental car on a Memphis bridge.

Don C. Wiley was in town to visit relatives and attend the annual meeting of
the scientific advisory board of St. Jude's Children's Research Hospital.
Police said there were no signs of foul play, just the car with the keys in
the ignition on a bridge that spans the Mississippi River. Police found the
car five hours after Wiley left a dinner at a posh hotel several blocks from
the bridge.

''This is totally unexpected. He was fine on Thursday night,'' said Dr.
Joseph Mirro, executive vice president at St. Jude's Hospital.

The disappearance of the popular, gregarious scientist has shaken the
scientific board and the staff and directors of the hospital, Mirro said.

''This is a terrible event and a great loss to the scientific community,'' he
added, assuming the worst. ''He is an extremely brilliant scientist in
medicine and understanding biology.''

In Cambridge, Wiley's wife, Katrin Valgeirsdottir, said she was planning to
fly down on Friday to meet her 57-year-old husband with their children, ages
7 and 10. He also has two other children, ages 26 and 34, she said.

''He would never vanish. He wouldn't commit suicide,'' she said. ''I have no
idea what has happened.''


An award-winning professor of biochemistry and biophysics at Harvard, Wiley
built the first model of the structures of influenza viruses and human cells
that allow the disease organism to infect humans.

In 1985, Wiley began researching how drugs might block the process, using a
method called X-ray crystallography, in hopes of conquering maladies ranging
from the common cold to HIV.

The researcher for the Howard Hughes Medical Institute at Harvard had flown
to Memphis Wednesday evening, police said, and stayed with his father in
Germantown, a suburb. Wiley's brother and sister-in-law also live in the
area.

On Thursday, Wiley met with the other 14 members of the board, and was one of
150 people attending a dinner that evening.

Memphis police Lieutenant Joe Scott said that witnesses described him as
being in a good mood when he left the dinner.

''No one detected that he was despondent or was having any difficulties in
any way,'' Scott said.

At 4 a.m. Friday, police found Wiley's rented Mitsubishi Galant on the
Hernando DeSoto Bridge, which links Tennessee to Arkansas.

Memphis police said the doors were unlocked, the key was in the ignition, and
the hazard lights had not been turned on. The car had a full tank of gas.

Scott said the bridge is about 100 feet high, and has been the scene of a
handful of suicides each year. Sometimes the bodies aren't found for weeks,
he said.

''We are investigating every angle we can think of,'' Scott said.

Wiley's research focuses on the structure of viruses and proteins in the
human immune system.

Herman Eisen, an MIT professor emeritus and friend of Wiley's, said suicide
''just doesn't fit.'' Wiley ''was extremely successful at what he did. He
seemed stable and outgoing, he ran a large research group very effectively.
People held him in very high regard.''

Globe correspondents Fran Riley and Jana Benscoter contributed to this
report.



This story ran on page B1 of the Boston Globe on 11/21/2001.
© Copyright 2001 Globe Newspaper Company.

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