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Chip could lead to clone factories

A Californian company is working on a method of mass producing cloned embryos.

It has designed a silicon chip which has hundreds of tiny egg-sized wells
etched into it and each one has a tiny hole in the base.

If the chip full of eggs is spun in a centrifuge the dense nuclei are forced
out through the hole and each egg is then ready to have a new nucleus
implanted.

The process has already been perfected on sea urchin eggs and is about to be
trialled on cow eggs, according to New Scientist.

If Aegen Biosciences succeeds, the next step will be to perfect a way of
fusing new nuclei into the egg.

They hope to do this by fixing a lid to the chip with appropriately
positioned donor cells.

The system could produce hundreds or even thousands of cloned embryos at once.

At the moment the process has to be done by hand and has a high failure rate.

Dr Harry Griffin, at the Roswell Institute, Edinburgh, where Dolly was
created, was unconvinced.

He said: "This sort of approach of centrifuging out the nucleus was tried
with cattle eggs more than five years ago and has never been used
commercially, which suggests that it's not going to be revolutionising the
field.

"Also one wonders what is the point of developing an automated system when
the biggest problem is finding a supply of eggs."

Story filed: 19:57 Wednesday 30th January 2002



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