The key part of the log http://aws-logs.debian.net/2017/10/30/python-biopython_1.70+dfsg-2_unstable.log is this bit:
====================================================================== FAIL: test_index (test_BWA_tool.BwaTestCase) Test for creating index files for the reference genome fasta file ---------------------------------------------------------------------- Traceback (most recent call last): File "/<<BUILDDIR>>/python-biopython-1.70+dfsg/.pybuild/pythonX.Y_2.7/build/Tests/test_BWA_tool.py", line 102, in test_index % (cmdline, stdout)) AssertionError: FASTA indexing failed: bwa index -a bwtsw BWA/human_g1k_v37_truncated.fasta Stdout: ---------------------------------------------------------------------- This has been reported upstream, and we suspect it is due to a change in the command line tool bwa: https://github.com/biopython/biopython/issues/1431