Hi, I wanted to acknowledge that all your issues need to be addressed and resolved.
I filed an issue with SeqLib & htslib to ask to work out a public cram api. Personally I think option C would be best for a short term fix and option B for the long term fix. SeqLib issue: https://github.com/walaj/SeqLib/issues/21 htslib issue: https://github.com/samtools/htslib/issues/619 Diane.