If they are run in series, then wouldn't it be best to run the next scanner only if the previous scanner passed? In other words why scan the email again if it already failed one of the scanners?
The logic behind that is the only a small fraction of E-mail contains a virus. Since the majority of E-mail has to go through both scanners, having the viruses go through both doesn't take much extra resources. The benefit is that you can tell from the log files if both scanners are detecting viruses, and if one is not able to report the virus/file name, the information from the other can be used.
-Scott
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