I had the same issue and I disabling the default for Wayland also resolved it for me.
(I had to uncomment the line #WaylandEnable=false in /etc/gdm3/custom.conf.) Initially after updating from 17.04 to 17.10 I had no troubles. For me this mouse issue appeared some time after (not right away) using ppa:ubuntu-x-swat/updates for the latest Mesa releases. By the way, also mouse hovering over an element that would usually focus on hovering over it did not work for me in a Wayland session. -- You received this bug notification because you are a member of Desktop Packages, which is subscribed to gnome-shell in Ubuntu. https://bugs.launchpad.net/bugs/1747568 Title: Mouse clicks ignored in Wayland Status in gnome-shell package in Ubuntu: Incomplete Bug description: If I disable Wayland, mouse clicks start working again. Randomly started occurring sometime after initial install. Ubuntu 17.10 --- ApportVersion: 2.20.7-0ubuntu3.7 Architecture: amd64 CurrentDesktop: ubuntu:GNOME DisplayManager: gdm3 DistroRelease: Ubuntu 17.10 InstallationDate: Installed on 2017-10-27 (102 days ago) InstallationMedia: Ubuntu 17.10 "Artful Aardvark" - Release amd64 (20171018) Package: gnome-shell 3.26.2-0ubuntu0.1 PackageArchitecture: amd64 ProcEnviron: TERM=xterm PATH=(custom, no user) XDG_RUNTIME_DIR=<set> LANG=en_US.UTF-8 SHELL=/bin/bash Tags: artful third-party-packages Uname: Linux 4.15.0-041500rc9-generic x86_64 UpgradeStatus: No upgrade log present (probably fresh install) UserGroups: adm cdrom dip emby libvirt lpadmin plex plugdev sambashare sudo users video _MarkForUpload: True To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/gnome-shell/+bug/1747568/+subscriptions -- Mailing list: https://launchpad.net/~desktop-packages Post to : desktop-packages@lists.launchpad.net Unsubscribe : https://launchpad.net/~desktop-packages More help : https://help.launchpad.net/ListHelp