Hi,

There were a number of changes form Adobe Flex 4.0 to Adobe Flex 4.5 - the 
introduction of spark skinning for instance. 

These links may help:
http://www.adobe.com/support/documentation/en/flex/4/releasenotes_flex4_sdk.html
http://helpx.adobe.com/flash-builder/release-note/release-notes-flex-4-5-1.html

And to find out what changed since the move to Apache look at the release notes.
https://github.com/apache/flex-sdk/blob/develop/RELEASE_NOTES

Despite the number of changes you shouldn't need to change too much code but 
really the only way to find out is to give it a go as it will depend on exactly 
what sort of application you have and what features you are using. If you run 
into any issues just ask on the list.

Thanks,
Justin

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