There are voice analysis and speech processing toolkits like Covarep and Voicebox (see links below) that were coded in Matlab, because they were originally only prototypes. There has been talk of porting them to C++. My first thought, as you might imagine, was why not use D? However, I don't know if there are any performance issues, especially for real time systems (in speech recognition), talking about GC, or in fact any other issues (number grinding etc.).

A lot of the analysis tools are based on some sort of HMM (http://en.wikipedia.org/wiki/Hidden_Markov_model) and I think D could handle that elegantly.

https://github.com/covarep/covarep
http://www.ee.ic.ac.uk/hp/staff/dmb/voicebox/voicebox.html

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