I guess it depends on what you mean by "very loud" and "medium to large"! I run a gen 2 T-amp into a pair of regular bookshelf speakers. The room is a fairly standard sized bedroom, something like 12'x14' and I've never tried turning it to max, it'd be too loud. I wouldn't expect the same setup to work well in my living room which is three times the size (and with high ceilings).
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