I agree that this is an important detail. I generally use machines that have many different Python interpreters installed (some distro-provided and others in my home directory), and can easily imagine wanting them to have different behavior w.r.t. manylinux1 wheels.
Perhaps the option could be put in site.py, or somewhere in lib/pythonX.Y/configX.Y/? I'm not sure what the appropriate solution here is. -Robert
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