May by
        -with-postgres-libraries=/opt/local/lib/postgresql
Or    -with-postgres-libraries=/opt/local/lib
And why not using psycopg2?
It is beta, but i not has a proplem with it. Just edit django's
postgresql module to import psycopg2 and comment register-type
(psycopg2 use datetime.datetime internally - not mxDateTime)

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