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The U.S. Department of Energy (DOE), Office of Science (SC) announces the 
release of the FY-2025 Early Career Research Program (ECRP) Funding 
Opportunity: 
DE-FOA-0003450<https://science.osti.gov/grants/FOAs/-/media/grants/pdf/foas/2025/DE-FOA-0003450.pdf>.

This opportunity includes the following two research topics from the Biological 
and Environmental Research (BER) program:

Earth and Environmental Systems Sciences
Understanding and predicting processes regulating fluxes of trace gases from 
terrestrial ecosystems
Technical Contact: Brian Benscoter, 
[email protected]<mailto:[email protected]>

Submissions (preapplications and applications) are sought within the 
Environmental System Science (ESS)<https://ess.science.energy.gov/> program 
area scope that will improve fundamental understanding and predictability of 
processes regulating fluxes of key trace gases other than carbon dioxide (CO2) 
from terrestrial and terrestrial-aquatic interface ecosystems. While greenhouse 
gas dynamics broadly are a critical component of the Earth system, non-CO2 
trace gases have a disproportionately large influence on radiative forcing as 
well as disproportionately large challenges and uncertainties for observing and 
predicting the magnitude and spatiotemporal heterogeneity of their fluxes from 
ecosystems. Improved process based understanding and predictive-model 
representation of the production, transformation, transport, and fluxes of 
these trace gases, as well as the influence of environmental conditions on 
their regulation, from microbial to landscape scales are critical for assessing 
and predicting their influence on the Earth system. Furthermore, improved 
understanding of the regulation of hot spots/hot moments of trace gas 
biogeochemistry is a recognized gap in state-of-the-art process models. 
Submissions for this topic are expected to: focus on predictive, process-based 
understanding and model representation of non-CO2 trace gas flux dynamics from 
terrestrial ecosystems; delineate an integrative, hypothesis-driven approach; 
describe the existing needs/gaps in state-of-the-art models that motivate the 
proposed research (i.e., ModEx<https://ess.science.energy.gov/modex/>); make 
use of new measurements from field and/or laboratory experiments; and combine 
the data/information with modeling/simulation efforts.

Biological System Science
Systems biology and biosystems design of bioenergy-relevant microbes to enable 
production of next-generation biofuels, bioproducts, and biomaterials
Technical Contact: Pablo Rabinowicz, 
[email protected]<mailto:[email protected]>
Applications are requested for systems biology research to advance the 
development of emerging eukaryote or prokaryote model microorganisms and/or 
microbial consortia relevant for the production of biofuels, bioproducts, 
and/or biomaterials by converting lignocellulosic biomass, upcycling synthetic 
(petroleum-derived) polymers, or as a byproduct of photosynthesis. Applications 
that propose multi-omics approaches coupled with genome-wide design and editing 
technology development, in vivo or cell-free engineering, advanced predictive 
modeling, and high-throughput screening to understand and re-design biological 
systems with novel functional capabilities and biosynthetic potential are 
encouraged. Proposed studies could include, but are not limited to: 1) 
elucidation and/or engineering of relevant regulatory and metabolic networks, 
metabolic pathways, and/or signaling processes related to bioproduct synthesis 
by microbes or multispecies consortia; 2) development of synthetic biology 
tools to facilitate the study and manipulation of emerging microbial model 
systems; 3) understanding and modification of phenotypes involved in the 
deconstruction and conversion of plant cell walls or synthetic, 
petroleum-derived polymers, 4) understanding and/or improving the tolerance to 
stresses induced by a) altered biosynthetic pathways, b) the synthesis of 
industrial chemicals, and/or c) culture volume or other conditions; and 5) 
engineering microorganisms for the production of biominerals, inorganic-organic 
composites, and composites of inorganic materials and living cells (living 
materials), with wholly new properties not found in nature. A focus on emerging 
model systems to expand the breadth of platform microorganisms for genome 
engineering is encouraged. Genome engineering approaches that may contribute to 
carbon capture and sequestration to reduce atmospheric CO2 are also encouraged. 
Research on traditional model systems should be kept to a minimum. Applications 
should address biocontainment of the engineered organisms and consider 
potential unintended outcomes and biological escapes.

More information on the SC Early Career Research Program can be found here: 
https://www.energy.gov/science/listings/early-career-program.<https://www.energy.gov/science/listings/early-career-program>

DE-FOA-0003450- Early Career Research Program:  
https://science.osti.gov/grants/FOAs/-/media/grants/pdf/foas/2025/DE-FOA-0003450.pdf

Please note the schedule below.

The PI and anyone submitting on behalf of the PI must register for an account 
in PAMS before it will be possible to submit a pre-application. All PIs and 
those submitting pre-applications on behalf of PIs are encouraged to establish 
PAMS accounts as soon as possible to avoid submission delays.


  *   Deadline for Pre-applications (required): February 18, 2025; 5:00 pm 
eastern time
  *   Deadline for Applications: April 22, 2025; 11:59 pm eastern time


__________________________________________
Brian Benscoter, MSc PhD   (he/him)
Program Manager, Environmental System Science

Earth and Environmental Systems Sciences Division
Biological and Environmental Research
U.S. Department of Energy
email:  [email protected]<mailto:[email protected]>
mobile: 561-492-5606
https://www.energy.gov/science/ber/biological-and-environmental-research
https://ess.science.energy.gov<https://ess.science.energy.gov/>

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