James - controls won't be in HWE (switch labels so that "cases" are
now called "controls"), unless Pr(Case) -> 0.
Example: let Pr(A)+Pr(a)=1 and Pr(case | "Aa")=1. Then all controls
are "AA" and "aa" and so are not in HWE. This implies looking for the
difference in HW disequilibrium between cases and controls, instead of
assuming that controls are in equilibrium.
Dmitri
In sci.stat.edu James Cui <[EMAIL PROTECTED]> wrote:
> It is said that Marc Lathrop proposed a method for case-control studies,
> to test the Hardy-Weinberg Equilibrium (HWE) in cases given control are
> under HWE. But I cannot find the appropriate reference. Could anyone help
> with this reference or any other reference you know.
> Thanks,
> James.
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