Hello,
I am a general surgeon in a state hospital, Ankara, Turkey.
I performed a study on " different enteral nutrients and bacterial
translocation in experimental obstructive jaundice."
There was 5 groups of rats. Each group consists of 20 rats. Occurred
Translocation incidences in mesenteric lymph nodes were shown in
following table. My aim was to compare groups 2, 3, 4 with
control(group 1)
Transloc.yes Transloc.no total
Group 1 sham ligation of bile duct 1 19 20
(fed rat chow)
Group 2 bile duct ligated 9* 11 20
(fed rat chow)
Group 3 bile duct ligated 8** 12 20
(fed enteral diet)
Group 4 bile duct ligated 1 19 20
(fed enteral diet 2)
Group 5 bile duct ligated 1 19 20
(fed enteral diet 3)
*p=0.008
**p=0.02
By chi squared test I calculated this p values.
The reviewer commented that I should do bonferroni correction, find
adjusted p value and according to this adjusted value, I should say
significant or not. However, in no study have I read that the authors
had written that they had adjusted bonferroni correction, especially
in a comparision by chi square test.
If bonferroni was performed then adjusted p value would be
0.05/10=0.005,
10= nx(n-1) in our study. Thus our results would not be significant.
Is it appropriate to make bonferroni correction or simes correction in
this situation?
Indeed I want to compare groups 2, 3, 4 with group 1. So there would
be 4
comparison.Is simes procedure is correct? How can I make Simes
correction?
Can you help me ? Thank you
Bekir Kuru
[EMAIL PROTECTED]
=================================================================
Instructions for joining and leaving this list and remarks about
the problem of INAPPROPRIATE MESSAGES are available at
http://jse.stat.ncsu.edu/
=================================================================
