This email will give you details on the following
specialized/advanced courses offered by MathSoft,
Inc during August 2000 by Dr Frank Harrell:

1) S-PLUS for Statistical Data Analysis
2) Regression Modeling Strategies

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Course #1: S-PLUS for Statistical Data Analysis
View Full Course Description:
www.splus.mathsoft.com/splus/train/harrell_stat.htm

Course Description: This two-day course begins with a
quick summary of the S-PLUS language and objects and a
comparison of S-PLUS and SAS. This is followed by
methods for inspecting, re-coding, re-shaping, and
manipulating data, some of which use extensions of
S-PLUS found in the public domain Hmisc library written
by the instructor. Usage of S-PLUS for more advanced
statistical methods such as simulation and
bootstrapping is surveyed. Then basic sample size and
power calculations are discussed, followed by an
example using the Hmisc library to simulate power for
the Cox-logrank test for comparing event times in a
clinical trial in which drop-in, drop-out, and delayed
treatment response are present. Then major emphasis is
given to table making and S-PLUS and Hmisc graphical
functions useful in everyday exploratory work and to
present final summary statistics. The course concludes
with discussion of some tools for making analyses
reproducible, an important facit for regulatory and
other scientific review of final results. Advantages of
using S-PLUS in conjunction with the LaTeX document
processing / typesetting system for constructing
reproducible statistical reports and hyperlinked PDF
documents are discussed.

Dates/City: August 21-22 Chicago, IL

Price:  Commercial = $1050
                Government = $ 950
                Academic   = $ 950
                discount: Save $250 when you register for both 
                Frank Harrell courses
                Includes continental breakfast, p.m. snack, and course materials

Hours:          Days 1-2:  8:30am-5:00pm
                (Continental Breakfast: 8:00-8:30 daily)

For a more detailed course description, location information, and
other courses, please visit:
www.splus.mathsoft.com/splus/train/2000schedule.htm

Register:       - Call Kim Kelly at: 800-569-0123 x278
                - Email: [EMAIL PROTECTED]
                - Web: www.splus.mathsoft.com/splus/train/train_registration.htm
__________________________________________________________________________

Course #2:  Regression Modeling Strategies
View Full Course Description: 
www.splus.mathsoft.com/splus/train/harrell_regression.htm

Course Description: The first part of the course
presents the following elements of multivariable
predictive modeling for a single response variable:
using regression splines to relax linearity
assumptions, perils of variable selection and
overfitting, where to spend degrees of freedom,
shrinkage, imputation of missing data, data reduction,
and interaction surfaces. Then a default overall
modeling strategy will be described. This is followed
by methods for graphically understanding models (e.g.,
using nomograms) and using re-sampling to estimate a
model's likely performance on new data. Then the public
domain S-Plus Design library will be overviewed. Design
facilitates most of the steps of the modeling
process. Next, statistical methods related to binary
and ordinal logistic and survival models will be
covered. Four case studies will be presented: an
interactive exploration of the survival status of
Titanic passengers, a case study in data reduction and
modeling of an ordinal clinical diagnostic outcome, an
interactive case study in developing a survival time
model for critically ill patients, and a case study in
Cox regression. In the hands-on comput!  er lab,
students will develop, validate, and graphically
describe multivariable regression models themselves.

Dates/City: August 23-25 Chicago, IL

Price:  Commercial = $1200
                Government = $1100
                Academic   = $1100
                discount *Save $250 when you register for both 
                Frank Harrell courses
                Includes continental breakfast, p.m. snack, and course materials

Hours:  Days 1-3:  8:30am-5:00pm
                (Continental Breakfast: 8:00-8:30 daily)

For a more detailed course description, location information, and
other courses, please visit:
www.splus.mathsoft.com/splus/train/2000schedule.htm

Register:       - Call Kim Kelly at: 800-569-0123 x278
                - Email: [EMAIL PROTECTED]
                - Web: www.splus.mathsoft.com/splus/train/train_registration.htm


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