Whoops! Sorry, Ken. Made a mistake. You're design is orthogonal (see below).
A B C D E F A 1.0 0.0 0.0 0.0 0.0 0.0 B 0.0 1.0 0.0 0.0 0.0 0.0 C 0.0 0.0 1.0 0.0 0.0 0.0 D 0.0 0.0 0.0 1.0 0.0 0.0 E 0.0 0.0 0.0 0.0 1.0 0.0 F 0.0 0.0 0.0 0.0 0.0 1.0 I am also going to check the design I suggested, which has 25 trials, to be sure that is also orthogonal. Of course, as you said, this would be a main-effects only design. John ================================================================= Instructions for joining and leaving this list and remarks about the problem of INAPPROPRIATE MESSAGES are available at http://jse.stat.ncsu.edu/ =================================================================