I would use a general nonlinear mixed model so as to include morphine as a time varying covariate. This could be done with MLwin of SAS nlmixed.
Paul R. Swank, Ph.D. Professor, Developmental Pediatrics Medical School UT Health Science Center at Houston -----Original Message----- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] Behalf Of Scheltema, Karen Sent: Tuesday, April 01, 2003 2:05 PM To: [EMAIL PROTECTED] Subject: repeated measures with unequal numbers of repeated measures I am struggling with how to analyze the following design. Morphine is known to cause urinary retention, which can result in increased discomfort, LOS, $$, etc. I have an experimental protocol covering three types of surgeries in which patients are randomly assigned to treatment as usual or an additional drug to counteract the side effects of morphine. There are two outcome variables, urinary retention (yes/no) and pain level (0-10). Urinary retention is measured every 8 hours and pain level is measured every 4 hours. The catch is that not everyone is on morphine for the same length of time. In addition 24 hours of additional data is collected after the morphine is discontinued because the side effects of morphine hang around that long. How do I account for some people being on morphine for 24 hours (a total of 6 measures of urinary retention), and others for 48 hours (a total of 9 measures of urinary retention)? Karen Scheltema, M.A, M.S. Senior Statistician HealthEast Research and Education Department, Midway Campus 1700 University Ave W St. Paul, MN 55104 Ph: (651) 232-5212 fax: (651) 641-0683 mailto:[EMAIL PROTECTED] . . ================================================================= Instructions for joining and leaving this list, remarks about the problem of INAPPROPRIATE MESSAGES, and archives are available at: . http://jse.stat.ncsu.edu/ . ================================================================= begin 666 winmail.dat M>)\^(B,4`0:0" `$```````!``$``0>[EMAIL PROTECTED](````Y 0```````#H``$(@ <` M& ```$E032Y-:6-R;[EMAIL PROTECTED];"Y.;W1E`#$(`0V ! `"[EMAIL PROTECTED]"``$& M@ ,[EMAIL PROTECTED],'! `!``X`& ````(`!P$!`Y &`%P*```E````"P`"``$````+ M`",```````,`)@``````"P`I```````#`"X```````,[EMAIL PROTECTED]'@!P``$` M```]````<F5P96%T960@(&UE87-U<F5S('=I=&@@=6YE<75A;"!N=6UB97)S M(&]F(')E<&5A=&5D(&UE87-U<F5S``````(!<[EMAIL PROTECTED]'"^(RU4>?% M!U7TI4H=B"^P0Z /BW,```(!'0P!````'@```%--5% Z4$%53"Y2+E-704Y+ M0%542"Y434,N1415````"[EMAIL PROTECTED] ``8.`'#_H([EMAIL PROTECTED]"[EMAIL PROTECTED] M````````S'[EMAIL PROTECTED]<* ```#`!0.`0````L`'[EMAIL PROTECTED]) M$ [EMAIL PROTECTED] 4``*$)``!,6D9U`%%^20,`"@!R8W!G,3(UXC(#0W1E> 5! M`0,!]_\*@ *D`^0'$P* #_,`4 16/PA5![(1)0Y1`P$"`&-HX0K <V5T,@8` M!L,1)?8S!$83MS 2+!$S".\)][8[&!\.,#41(@[EMAIL PROTECTED],PL)`60S-A90"Z8@ [EMAIL PROTECTED]@;&[EMAIL PROTECTED]<"!A(&<)\ 20!T @*FX"(&P+@&4*P6UIGG@)@[EMAIL PROTECTED]'$# M('-O':#M!"!T'\ +@&,*0 $`'T&X<G!H'I$?TAVP= =QE"!V"L!Y"X!G( 6@ MQR'Q!S .L"[EMAIL PROTECTED]"$`!"#K!: =,F(=D&0"(!V0`_ T=&@%T$P#\ .@;V;[EMAIL PROTECTED] M!? ><![S([EMAIL PROTECTED] 4&$=, ?P(P!3=P$`<&LL(%!H+D2U)>90`V!F!Y ? ML'(GD,A$978?@&]P!X ",)T>(5 )@"+!!1!C<R8$JDTJ$6,>(5,3T&\&\*$F M!%54($@>L&PD<>\K@ B0(% =D$,IH1*!(M![+& (8',@$ N0)ADF"BWU+_)/ M!1!G"X >(2L`!! N81W0+_,[EMAIL PROTECTED] +C BT"UO=QWQ0!,>@"XP<RX@ M4'-U+G$)@'[EMAIL PROTECTED] `Q @$#J3,E\S:%U/+F5"91/@^FPE$$\E$1/0'X .L # M_2>02PK "? F! [EMAIL PROTECTED] R,$)4"E!S9&%Y)Y!!9G %$ ,@,#$GD '0,*(S.E Z M,#4GH$TF!&94-' R1FQ -+(Z<'>/,V TLC-W.'5U8FH%D/LY`1@@<!ZP#K ? M,1ZP,Z"7&" $("13=1WP<74>(GYU!M $D 0@)0$^KR[?"AD<\&%M'Z J4'5G M9_\>@2)0)%,KH ?@(!$`< = O'EZ'9 D<!V0`A!L%["/),$B4 $``)!G;BXF M"O9-(-8C06L>4#40( (K0'\=<@AQ,) B$$$Q#K ",&G[`B GD'<A`!/020$# MH#^!_QTP!4 DT2!!&" ?X!\A*B ?!/ #< (0`" GD$Q/4]DGD"0D)Y 4(&,C M`!SA[Q/@*4!%(3) >#[ !1 IE?TYT&[EMAIL PROTECTED]>1(F(&<2)!)'#["[EMAIL PROTECTED]'D^P$#S M/V$=T B!_P0@)-%*I JP(: IH2%A&"#W03 `<"0`;45@']%&LA\A_R 1*E ^ MT2F2'](=<$!2!;&Y`Y%A9"[EMAIL PROTECTED](>(61#X?]([EMAIL PROTECTED](`T 5 1;(`D""1_P$1 M/E% \R#&[EMAIL PROTECTED]( 20'9'M4X%T'1 D\'5-X -P(=,?!S "8 >0)Y!)?R H>?4' MD"\>4"E%(1U0"K DT0=<("E!78 P+3$P*?U.`55<CR-!/S4=4"DQ2<$^.$2Q M"' A85X\8,[EMAIL PROTECTED]/]A]%HT20%-X"2 (T$D<"[EMAIL PROTECTED](T%=82#'3.'_ M6&1#D!V07" B0"1Q)0$AHO].`E9X.E!D=23R5IHBT!VP[R-#1A ^41\A80& [EMAIL PROTECTED](-*,4"0'R$CT$D4_UA_68E.02)!"L!7T52Q9?+_%[ B0",` [EMAIL PROTECTED]'X"0`'.$`T/]7PV?C'[ AP3[ *7!<("/!]R([EMAIL PROTECTED]@4_ 5@(E$.XV M/[EMAIL PROTECTED]>07B)/P+=:<[EMAIL PROTECTED](T8>9W&CEW[SUX_#].$"8*.",W:DTN>D& M$E-&]3C12E %P%._-,$S,[EMAIL PROTECTED] N92QT11_@>G0F!%('D!ZQ2M%>(D7_,^!E M45U2*2 [EMAIL PROTECTED](&LG4$G00T.0<!UP)@0Q_C<Z<%^0`P!040"042 0P'U. M<5<X=3T0)Z FT8 13E8@&[EMAIL PROTECTED],"B&[EMAIL PROTECTED]@`R,S(M#D G#B!.$$7@ M87B*9C8TX#$M,#8X%3 F$S0E]FL$\#>50#>0+)(_03T0W06P9R8*1O5&]3V0 MSY'?_Y+OD\M#%0" 0]$^8$I1>H3\:F\+@"(R7B)<([EMAIL PROTECTED](3?(T$S(B>0&" ` MP'[EMAIL PROTECTED];@6U!%HB8$3Z%<$4.@)0& 24Y!4%!23YJ0D$E!5$4%T$53)3#^ M1YM >=2#\H>!4U1.8#0QNUP"+<$ZCX6+89X]: ) 8' Z+R]J%! \W"]_GC^+ M89!?HQ^D+Z4_E)A]`:<`'@!"$ $````_````/[EMAIL PROTECTED](Y M04(R0C!&13<Y0CDR-T,[EMAIL PROTECTED],3E#0&TP;6%I;"YH96%L=&AE87-T+FQO8SX` M``,`"5D!````"P``@ @@[EMAIL PROTECTED] ```````$8``````X4````````#``* M"" &``````# [EMAIL PROTECTED],`!X (( 8``````, ````` M``!&`````%*%```_<0$`'@`)@ @@[EMAIL PROTECTED] ```````$8`````5(4```$` M```$````.2XP``L`$8 (( 8``````, ```````!&``````:%`````````P`2 M@ @@[EMAIL PROTECTED] ```````$8``````84````````+`!N "" &``````# ```` [EMAIL PROTECTED],`'( (( 8``````, ```````!&`````!&%```` M`````P`>@ @@[EMAIL PROTECTED] ```````$8`````&(4````````"`?@/`0```! ` M``#,>:_6"%1"2Y*BC*>JW??M`@'Z#P$````0````S'[EMAIL PROTECTED] M[0(!^P\!````E `````````XH;L0!>40&J&[" `K*E;"``!M<W!S="YD;&P` M`````$Y)5$'[EMAIL PROTECTED]<1&]C=6UE;G1S(&%N9"!3971T:6YG M<UQP<W=A;FM<3&[EMAIL PROTECTED]&EN9W-<07!P;&EC871I;[EMAIL PROTECTED]&%T85Q-:6-R M;W-O9G1<3W5T;&]O:UQM86EL8F]X+G!S= `#`/X/!0````,[EMAIL PROTECTED] M``$````Q````,# P,# P,#!#0S<Y049$-C X-30T,C1".3)!,CA#03=!041$ M1C=%1#(T0S0U-# P``````,`!A",<#[E`P`'$'8&```#`! 0``````,`$1 ` M````'@`($ $```!E````25=/54Q$55-%04=%3D5204Q.3TY,24Y%05)-25A% M1$U/1$5,4T]!4U1/24Y#3%5$14U/4E!(24Y%05-!5$E-159!4EE)3D=#3U9! ?4DE!5$542$E30T]53$1"141/3D57251(30````"GV0`` ` end . . ================================================================= Instructions for joining and leaving this list, remarks about the problem of INAPPROPRIATE MESSAGES, and archives are available at: . http://jse.stat.ncsu.edu/ . =================================================================
