Greetings,

In the textbook treatments of WLS or GLS it is typically assumed that
the error covariance is known.  In some discussions it is remarked
that estimates of the error covariance can also be used.  This is
certainly the case in my scenario -- the error covariance is
experimentally estimated.  However, I'm struggling a bit at the
moment, because it seems to me that the presented variance expressions
for the coefficients in WLS/GLS don't reflect the uncertainty
associated with estimating the error covariance.  For example,

y = Xb + e
var(bhat) = MSE*inv(X'*W*X)
where W = inv(cov(e))

It seems to me that if W is weakly estimated, the resulting intervals
on bhat must be very wide, regardless of the experimental design.

Does anyone have any "2-cents", or references to a treatment of this
topic?

Thanks in advance,
C.
.
.
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