Hi, the big advantage of the mesa-boards is that they are well suited to drive relays and other kinds of devices. An Arduino or similar board only has TTL or CMOS IOs which need to get adapted to your actual IO voltages/currents. Parallel Ports also need some additional protection/drivers to handle 'realworld' IO.
Depending on the actual project it might be possibe to design you own IO-Board with appropriate IO circuits.
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