Hello Prabhu,

Use SUBSTITUTE. or excel's Find/Replace command

SUBSTITUTE is a case sensitive function, so you need convert the cell to 
UPPER or LOWER, so use,

=SUBSTITUTE(UPPER(A1),"ABC","")

Or,

=SUBSTITUTE(LOWER(A1),"abc","")

All the letters in 1st output will be in CAPITAL LETTERS
All the letters in 2nd output will be in small letters.

If you need the results as the same as original, Try this,

=INDEX(SUBSTITUTE(A1,{"ABC","abc"},""),MATCH(MIN(LEN(SUBSTITUTE(A1,{"ABC","abc"},""))),LEN(SUBSTITUTE(A1,{"ABC","abc"},"")),0))

Or use Find/Replace command. select the range, Press Control+F

Find What: abc
leave the Replace with blank, then click Replace All

HTH
Haseeb

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