You could monitor the message tracking logs for deliveries into the mailboxes 
from each sender, and when some pre-determined counter is reached, trigger an 
email?

From: bounce-9480425-8066...@lyris.sunbelt-software.com 
[mailto:bounce-9480425-8066...@lyris.sunbelt-software.com] On Behalf Of Paul 
Cookman
Sent: 27 January 2012 11:33
To: MS-Exchange Admin Issues
Subject: Email misuse alerts.

Any ideas of a way to get alerted if a threshold of emails is reached between 
two users?

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