That sounds more like a DNS corruption issue.

Have you tried flushing your DNS cache?

From: Steve Ens [mailto:stevey...@gmail.com]
Sent: Wednesday, December 05, 2012 3:11 PM
To: MS-Exchange Admin Issues
Subject: Re: DNS query failed

Mine (and the other senders trying to get to theirs).

On Wed, Dec 5, 2012 at 1:06 PM, Campbell, Rob 
<rob_campb...@centraltechnology.net<mailto:rob_campb...@centraltechnology.net>> 
wrote:
Did their server issue then NDR, or yours?

From: Steve Ens [mailto:stevey...@gmail.com<mailto:stevey...@gmail.com>]
Sent: Wednesday, December 05, 2012 3:02 PM
To: MS-Exchange Admin Issues
Subject: DNS query failed

So I am getting an error back from a particular domain saying 4.4.0 DNS Query 
failed when trying to send mail.  Now I can fix this error at my end by 
checking external DNS server in the send connector network settings (exchange 
2010). However this particular domain is having problems with receing from 
multiple senders.  I spoke with their admin today and he is pulling out his 
hair.  Could it be that they are checking SPF records?  He is running exchange 
2007.

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