This is the right answer:

http://serverfault.com/questions/420191/ntuser-dat-and-usrclass-dat-files-building-up-by-the-thousands-why-and-can-i-de

From: Richard Stovall [mailto:rich...@gmail.com]
Sent: Wednesday, January 9, 2013 11:48 AM
To: MS-Exchange Admin Issues
Subject: regtrans-ms and blf files

I backup my single Exchange 2010 server (running on 2008 R2) every night using 
Windows Server Backup.

I'm running a bit low on system drive space and I discovered that every night 
when the backup runs, three files are created in two separate locations that 
are never deleted.  The file names and locations are:

c:\users\accountname\
   ntuser.dat{long_GUID_here}.TMContainer00000000000000000001.regtrans-ms
   ntuser.dat{long_GUID_here}.TMContainer00000000000000000001.regtrans-ms
   ntuser.dat{long_GUID_here}.TM.blf

c:\users\accountname\appdata\local\microsoft\windows\
   usrclass.dat{long_GUID_here}.TMContainer00000000000000000001.regtrans-ms
   usrclass.dat{long_GUID_here}.TMContainer00000000000000000001.regtrans-ms
   usrclass.dat{long_GUID_here}.TM.blf

The backup process writes its output to a network share on another server using 
a domain service account configured using the server backup wizard.  The 
offending files are created in the profile of the service account on the 
Exchange server.

The regtrans-ms files are always 512k and the blf files are always 64k.  Across 
the two locations, these files are consuming 1.4GB of disk space.  (The backups 
have been running this way since 3/21/2011, so there are almost 2000 files in 
each location.)

Is it safe to delete these files?  I can't find much documentation about them, 
but they appear to be related to registry transactions made as part of the 
backup process, and my guess is that they aren't being deleted properly for 
some reason.  The backups complete successfully and there are no related errors 
in either the application log or the system log.  The only entries there 
indicate successful backups.

If it matters, the backup type is "Full server" and the WSB "Performance 
Settings" value is set to "Normal backup performance."

Thanks for any ideas about this,

RS

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