The link can be found here:
"Although examples in the present invention will be described
below, it is to be understood that the invention is not limited to these
examples. Blood cell count is represented in units of microliters
(/.mu.l)."
Example 1
A recombinant feline .omega.-interferon preparation (Trade
Name: INTERCAT) was administered to a 6-month-old crossbred male cat which was
observed to have neutropenia due to a feline leukemia virus infection.
On the first day of examination, the cat weighed 3.7 kg and
had a body temperature of 39.5.degree. C., had completely lost its
appetite, lost vigor, and was observed to have gingivitis and purulent
rhinorrhea.
Blood test results were as follows: PCV 41%,
WBC 8,800,
neutrophil 484,
lymphocyte 3,256,
monocyte 5,016,
eosinophil 44, and
thrombocyte 200,000.
WBC 8,800,
neutrophil 484,
lymphocyte 3,256,
monocyte 5,016,
eosinophil 44, and
thrombocyte 200,000.
In the virus test, an FeLV antigen was detectable and an FIV
antibody was not detectable.
The INTERCAT was dissolved in a physiological saline
solution, and was subcutaneously injected, at a dose of 4 MU/day, for
three days. The dose was 1.08 MU/kg per cat weight. A transfusion
(lactate Ringer's solution and glucose) was injected by intravenous drip
infusion at a dose of 500 ml/day, and an antibiotic (cephalexin) was
intravenously injected at a dose of 150 mg twice a day.
On the third day, the cat regained its appetite and had a
body temperature of 38.2.degree. C. and a weight of 3.6 kg. Blood test results
were as follows: PCV 40%, WBC 10,100, neutrophil 2,121, lymphocyte 5,555,
monocyte 2,121, eosinophil 303, and thrombocyte 100,000. Significant increases
in the number of neutrophils and lymphocytes were observed, alleviation of fever
and improved general condition were observed, and gingivitis and purulent
rhinorrhea were cured.
However, on the seventh day, the cat had a body
temperature of 40.2.degree. C. and had lost appetite and vigor, and
discharges from the eyes and lingual erosion were observed. Blood test results
were as follows: PCV 29%, WBC 8,500, neutrophil 1,530, lymphocyte 2,550,
monocyte 4,420, eosinophil 0, and thrombocyte 200,000.
The INTERCAT was subcutaneously injected 4 times at a
dose of 4 MU/day, every other day. As combined remedies, on the day
when the INTERCAT was administered, a transfusion (lactate Ringer's solution and
glucose) was injected by intravenous drip infusion at a dose of 500 ml/day, and
an antibiotic (cephalexin) was intravenously injected twice a day at a dose of
150 mg.
On the 12th day, body temperature had decreased to
38.3.degree. C., and appetite and vigor were regained. Blood test results were
as follows: PCV 32%, WBC 17,200, neutrophil 8,084, lymphocyte 6,880, monocyte
2,236, eosinophil 0, and thrombocyte 200,000.
On the 19th day, although no abnormalities were
observed when the cat was examined, as a precaution, a dose of 4 MU of INTERCAT
was subcutaneously injected.
After one month, it was recognized that the FeLV
antigen level had become undetectable. The cat weighed 4.05 kg. Blood
test results were as follows: PCV 39%, WBC 19,300, neutrophil 3,492, lymphocyte
8,299, monocyte 1,158, eosinophil 1,351, and thrombocyte 200,000.
After one year, the FeLV was also
undetectable. The cat weighed 4.5 kg. Blood test results were as
follows: PCV 42%, WBC 7,100, neutrophil 3,763, lymphocyte 2,982, monocyte 71,
eosinophil 284, and thrombocyte 200,000.
Take care,
Glenda
Our FeLV/FIV kitties & other stuff:
http://community.webshots.com/user/sicky_icicle
http://community.webshots.com/user/sicky_icicle
