The cat with the ear tumor would be MUCH better off long-term by having the ear removed than by being on pred long-term. There is a very involved, but effective total ear abalation surgery that removes the entire ear canal, including the inner and outer ear, and usually leaves a normal looking ear flap, but if the tumor involves the flap, you could take that as well. If it's only on the flap, of course, that's VERY easy to remove.
I have not heard of Pred being used for seizures, but I could be wrong there. The extreme nasal discharge you are describing sounds like it began as a Herpes outbreak, or possibly Calici, and has since turned into a bacterial nasal infection in some of your cats. I would advise stronger or different antibiotics if you are not seeing improvement within 1 week of starting your current antibiotics. Another thing worth trying is testing the mucous for fungal infection, which often is something that is overlooked unless the owner specifically requests it be checked for. Here is a lab service that can test for most URI issues: http://www.zoologix.com/dogcat/Datasheets/FelineRespiratoryPanel.htm But, I would consider also doing a fungal test, at least for the most common nasal fungal infection, Cryptococcosis, as it is a serious issue if left untreated (the fungus can eat out the bones in the face if left to fester - it can also lead to some of the other symptoms you mentioned in your other cats, like blindness, and seizures - it's all around a NASTY thing that should be seriously considered if antibiotics do not help). http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2003&PID=6653&O=Generic Phaewryn http://ucat.us/domesticcatlinks.html Special Needs Cat Resources http://www.iGive.com/html/refer.cfm?causeid=21303 Sign up for iGive and a percentage of your purchases helps save animals!