We usually givery Doxycycline liquid at the shelter. If given in pill form water has to be forced down throat as well because of issues with damage to esophagus.
I have never heard of doxy as a chewy treat. That is great. My default is transdermal :-). On Sun, May 13, 2018, 2:22 PM ROBERT CHAPEL <bcha...@optonline.net> wrote: > My recollection re: the stand against Doxy Tabs is that they are often > large and hard to get all the way down the cats throat without getting > stuck.... I DO apologize that it's been so long since I was giving my > cats Doxy in pill form successfully( had found a coated small pill).... > but... if you can afford it ...diamondback drugs can formulate tasty > chewies with Doxy that many cats love ( mine ate them down with relish) > Believe Sandy might be able to weigh in on this??.... Don't have > experience with liquid form... but be assured there iis always a way a > drug can be administered to a cat... if one has the time, ability and > funds.... The chewies are not cheap.... > > Bob in Warwick NY > > > On Sun, May 13, 2018 at 01:44 AM, felvtalk-requ...@felineleukemia.org > wrote: > > > Send Felvtalk mailing list submissions to > > felvtalk@felineleukemia.org > > > > To subscribe or unsubscribe via the World Wide Web, visit > > > > http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > > > > or, via email, send a message with subject or body 'help' to > > felvtalk-requ...@felineleukemia.org > > > > You can reach the person managing the list at > > felvtalk-ow...@felineleukemia.org > > > > When replying, please edit your Subject line so it is more specific > > than "Re: Contents of Felvtalk digest..." > > > > > > Today's Topics: > > > > 1. Re: Anemia and Aranesp (Maribel Piloto) > > > > > > ---------------------------------------------------------------------- > > > > Message: 1 > > Date: Sun, 13 May 2018 01:43:43 -0400 > > From: Maribel Piloto > > > To: felvtalk@felineleukemia.org > > Subject: Re: [Felvtalk] Anemia and Aranesp > > Message-ID: <4371704d-888f-47a3-9163-24187c493...@bellsouth.net> > > Content-Type: text/plain; charset="utf-8" > > > > Hi Amani and everyone else who?s been helping me with this post - I > > shared the recommended drug protocol with a friend of mine who isn?t a > > vet but has worked for years in animal rescue and has also worked at > > both the local Humane Society and the local county shelter. She also > > attends a lot of vet conferences. She sent me the following... > > > >> If your vet is willing to prescribe this regimen, I'd give it a try > >> with one CRITICAL CHANGE. NEVER use doxycycline tablets/capsules > >> with cats as doxy can cause esophageal strictures. You can get > >> compounded doxycycline is 50 mg/ml, so dose would be 0.4 - 0.5 ml > >> twice a day. > > > > Do you foresee any issues with using the Doxy in liquid format? I > > also wanted to get the Prednisolone in liquid as Flaqui is very > > difficult to pill. > > > > Thanks > > Maribel > > "The greatness of a nation can be judged by the way its animals are > > treated." > > -Mohandas Ghandi > > > >> On May 10, 2018, at 11:02 PM, Amani Oakley wrote: > >> > >> Thank you Sandy. You saved me from repeating what I have posted so > >> very often now. > >> Mirabel, regarding the Aranesp, it is a product which mimics the > >> effects of erythropoietin. I do not believe it will assist because > >> erythropoietin tells the bone marrow to produce more red cells. With > >> FeLV, it infects the cells in the bone marrow which produce all three > >> cell lines (red cells, white cells, platelets). The cells are taken > >> over and destroyed by the virus, which means that the bone marrow can > >> no longer produce red cells, white cells and/or platelets. The > >> erythropoietin or Aranesp is speaking to these cells and telling them > >> to churn out more red cells, but the bone marrow cells can no longer > >> do that. My experience with the Winstrol is that after my cat had the > >> very worst results (HAEMATOCRIT OF FIVE!!!, ZERO % RETICULOCYTES, > >> etc.) and AFTER I had given him several bouts of blood transfusions, > >> the Winstrol turned back on the bone marrow and he began producing > >> red cells, white cells and platelets again. > >> Amani > >> From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On > >> Behalf Of Sandy > >> Sent: May-10-18 8:48 PM > >> To: Maribel Piloto; felvtalk@felineleukemia.org > >> Subject: Re: [Felvtalk] Anemia and Aranesp > >> This is long because I just copied this whole conversation - but > >> your answer lies in this combination of drugs - make no mistake this > >> will work if your vet will give it a try - there is nothing to lose - > >> BUT you and the vet need to act immediately. - good luck. You will > >> probably get more responses - Sandy W > >> > >> > >> Winstrol ? 1 mg twice a day > >> > >> Doxycycline ? 1/5 to ? tablet (100 mg) twice a day > >> > >> Prednisolone ? ? 5 mg tablet, twice a day > >> > >> If there are problems with the intestines (vomiting, constipation, > >> slow moving stools, stools of large diameters, all of which might be > >> indicative of the effect of the virus on the intestines) you can try > >> adding ? tablet of apometocloprimide. > >> > >> If the haematocrit level is REALLY REALLY low ? like below 5-8, you > >> might consider starting the Winstrol at 2 mg twice a day for a week, > >> to try and kickstart things quickly, but given that there is going to > >> be a likely increase in liver enzymes with the use of Winstrol, > >> recognize that this might also increase the liver enzymes faster. > >> > >> Hope this helps! Amani > >> > >> > >> From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On > >> Behalf Of gary > >> Sent: January-27-17 4:04 PM > >> To: felvtalk@felineleukemia.org > >> Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV > >> > >> Amani, > >> > >> Could you please give the dosages used for Zander's Protocol? I know > >> they must have been previously given, but I cannot seem to find them. > >> > >> Thanks, Gary > >> > >> On 9/16/2016 8:52 AM, Amani Oakley wrote: > >> > >> Hi Sherri > >> > >> I hope you got some good news today. However, as you know, my > >> experience is that the Winstrol needs to be used long term before the > >> red cells are back into the normal range. I continue to recommend use > >> of the Doxycyline to interfere with viral RNA synthesis. The Winstrol > >> does not attack the virus, though I believe it makes the cat stronger > >> overall and able to fight back. But at the outset of the treatment > >> regime, I believe you must have the Doxycycline on board to try and > >> reduce the viral load, or at least, keep it from rising. > >> > >> Amani > >> > >> _______________________________________________ > >> Felvtalk mailing list > >> Felvtalk@felineleukemia.org > >> > >> http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > >> > >> Hi Liz > >> > >> The only thing that works to turn back on red cell production is > >> Winstrol (Stanazolol). It is an ANABOLIC steroid (as opposed to most > >> steroids we are used to getting, like prednisone, which is a > >> corticosteroid. > >> > >> Anabolic steroids are ones which build muscle, tissue, etc. > >> > >> Adding Winstrol to the combination of medication you have your cat on > >> right now, would be the best thing to do. The Doxycycline acts to > >> slow down or inhibit the reproduction of the FeLV virus by > >> interfering the RNA duplication. The prednisone is helpful in keeping > >> inflammation at bay, but neither of these helps to increase the red > >> cells. The Winstrol acts directly and very quickly on the bone marrow > >> and seems to get red cells generated again, quite promptly. At least > >> it did for my Zander, and I have been contacted directly by several > >> people from this group, who have reported to me that they also saw > >> almost immediate (within 3 days) evidence of their cats? > >> gums/ears/pads pinkening up. > >> > >> The problem is that Winstrol is a controversial drug because it is > >> also what professional athletes use to get bigger, stronger and > >> faster. Quite unfortunately (since none of our cats are entering the > >> Olympics) that association with doping scandals has cast a shadow on > >> its use in both animal and people medicine. In human medicine, it is > >> the only drug found to be effective in treating hereditary angioedema > >> and anemia. > >> > >> Here is a blurb I found about it: > >> > >> Winstrol was first invented in 1959. Soon after that, the UK based > >> Winthrop Laboratories created a prescription medicine from it. Later, > >> in 1961, Winthrop?s patent was bought by the US based Sterling that > >> started manufacturing and selling the drug in the American markets. > >> > >> In the beginning, Winstrol was used for a variety of medical reasons. > >> But later, by the 1970s, the FDA had restricted its use to only > >> promoting growth and treating osteoporosis. In the 1980s, there was a > >> termination of the manufacture of anabolic steroids in the American > >> market. But Winstrol was among those steroids which not only > >> survived, but thrived in the 1980s and 1990s. During this period, its > >> use was reinforced as a cure for anemia ? as it had the power to > >> boost red blood cell count, and was used as a treatment for facial > >> swelling or angioedema. > >> > >> When the manufacture of Winstrol was finally discontinued, Ovation > >> Pharmaceuticals bought the rights to manufacture it, in 2003. > >> However, Ovation Pharmaceuticals have ceased their operations now, so > >> the Winstrol products available today in the American markets are > >> only generic and not pharmaceutical grade. Outside the USA, however, > >> several large brands still manufacture and sell Winstrol. > >> > >> Genuine Stanozolol can be distinguished in water suspensions because > >> it separates from the liquid into micrometer particles. These > >> particles will fall to the bottom if the container is not disturbed > >> for a few hours. The crystals have a milky white color. > >> > >> Winstrol can not only be used for humans, but it has veterinary uses > >> as well. Weakened or injured animals can be treated with Winstrol in > >> order to promote red blood cell count, strengthen bones, stimulate > >> appetite, and enhance muscle growth. It has also reportedly been used > >> to dope horses in US horse races. > >> > >> If your vet is willing to try this, he/she will need to order it from > >> a compounding pharmacy. > >> > >> The dose should be 1 mg 2 times a day for a cat. If your cat is in > >> poor shape and needs an immediate boost, start him on 2 mg x 2 times > >> a day for a week or so, and then drop down to the lower dose. > >> > >> Your vet will undoubtedly say that Winstrol is known to cause liver > >> damage. > >> > >> The first answer to this is, so what? FeLV will almost invariably > >> result in the premature death of cats. The vets have nothing which is > >> directly effective to fight FeLV. Things like Interferon may or may > >> not assist but such a treatment is again a side treatment where you > >> are hoping to boost your cat?s immune system, rather than a direct > >> attack on the virus. It is also quite indirect in that IF the > >> interferon helps, it will be more long term, and only if it manages > >> to boost the immune system enough to permit your cat?s system to try > >> and fight the virus, and when/if the virus is inhibited enough, then > >> MAYBE (if the virus hasn?t already destroyed all the progenitor cells > >> in the bone marrow) will red cell production begin to climb again. > >> Winstrol is the only medication that I know of, (and believe me, I > >> have looked!) that seems to work by turning back on those progenitor > >> cells or possibly promoting the growth of new ones since it also > >> works to enhance the production of bone cells (effe > > ctive against osteoporosis). > >> > >> The second answer, regarding the liver damage, is that the only > >> information about this is quite suspect, coming out of a very poorly > >> designed research study where the cats in the study were given doses > >> found effective on HUSKY SLED DOGS for lord?s sake! The cats were > >> given a LOADING DOSE via intravenous injection, of 25 mg ? more than > >> 10 times the recommended daily dose for cats. That?s the only study > >> which has found this supposed link between Winstrol and liver damage. > >> And even in that study, with those remarkably ridiculous doses, the > >> cats in that study only had elevated liver enzymes (no tumours, etc.) > >> and the liver enzymes dropped back to normal levels when the Winstrol > >> was discontinued. This is consistent with my experience as well. I > >> refused to stop the Winstrol for my cat, when the enzymes went up, > >> because he was going to die with the low red cell count he had. I > >> kept him on Winstrol for around 10 months, before the red cells were > >> in a normal range. During that ten month per > > iod, I would wean him down a few times, but ALWAYS the red cells > > would immediately drop again, so it was more than clear that it was > > the Winstrol making the numbers rise. So, in the end, he had Winstrol > > pretty much for the duration of 10 months and his liver enzymes went > > right back to normal again, once I discontinued the Winstrol ? NO > > lasting damage. This was also my experience with a second cat with a > > nasal sarcoma, and where I used the Winstrol to keep her appetite up > > and reduce the swelling (she was 16). The enzymes went quite high at > > the outset of my use of Winstrol, but went back to normal when I > > weaned her off for a bit and then again when I ultimately took her off > > the Winstrol. > >> > >> Get the Winstrol if you can, and use it in combination with the > >> prednisone (which I am told also helps to protect the liver when the > >> Winstrol is used) and Doxycycline. > >> > >> Amani > >> > >> From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf > >> Of Liz McCarty > >> Sent: September-15-16 1:40 PM > >> To: felvtalk@felineleukemia.org > >> Subject: [Felvtalk] My baby recently diagnosed with FeLV > >> > >> Hi everyone, > >> > >> Looking for support, suggestions, and information. I've never had a > >> cat with FeLV. We took our 1 year old, Hodor, to the vet because he > >> seemed lethargic and in his stool there was a piece of floss that was > >> red. At the vet things escalated and they told us he was severely > >> anemic and would need a transfusion that day. I took off work and > >> rushed him to a specialist. The vet there told us she would run an > >> FeLV test before doing anything in case we wanted to avoid the extra > >> tests and procedures. She told us he was FeLV positive and > >> persistently talked to me and my fiance about euthanizing him which > >> was out of the question for us. I took him to the vet thinking it was > >> going to be minor and then she's talking to me about killing him! We > >> went forward with the blood transfusion. It's been almost 3 weeks > >> now. They had him on doxycycline in case there was a bacterial > >> cause, and prednisone. Last week he started interferon... Does anyone > >> have experience with that and know if it was effective? > > I also started him on Pet Tinic. Any other suggestions? Any insight > > into whether you think he will be able to pull through? He doesn't > > have cancer, they ran the tests but don't know if it's in the bone > > marrow. I'm scared. We have another one year old, unrelated, and they > > are best friends. It breaks my heart to think they might be separated. > > She's not FeLV positive. > >> > >> Additionally I have set up a go fund me to help with the costs we > >> incurred, and I want to donate half to FeLV research if anyone is > >> interested. http://www.gofundme.com/2mzdpgk > >> > >> Mainly looking for support and advice. Thank you in advance. > >> > >> Elizabeth McCarty, ASW #36438 > >> > >> On May 10, 2018 at 4:09 PM Maribel Piloto > wrote: > >> > >> Hi all, > >> I have a Leuk+ girl who is getting very anemic. Her name is Flaqui. > >> She showed up at one of the colonies I feed a couple of months ago > >> (already spayed) and was so thin I thought she was an elderly cat > >> with not much time left so I took her home to give her some comfort > >> in her final days. When I took her to the vet it turned out that she > >> isn't that old (vet things 4-5) but she's Leuk+. I decided to keep > >> her in my room where I have another Leuk+ guy. I'm building a little > >> catio for them outside one of the bedroom windows so they can enjoy > >> the outside. > >> Flaqui's numbers in January 2018 were... > >> RBC - 4.15 M/ul (5.00-10.00) LOW > >> HCT - 20.2% (30.0-45.0) LOW > >> HGB 6.8 g/dl (9.0-15.1) LOW > >> MCV 48.7 fL (41.0-58.0) > >> MCH - 16.5 pg (12.0-20.0) > >> MCHC - 33.8 g/dL (29.0-37.5) > >> RDW - 20.5% (17.3-22.0) > >> %RETIC - 1.3% > >> RETIC - 53.2 K/uL (3.0-50.0) HIGH > >> WBC - 15.30 K/uL (5.50-19.50) > >> EOS - 1.8 K/uL (0.10-0.79) HIGH > >> PLT - 663 K/uL (175-600) > >> Everything else was normal > >> I started her on Liqui-Tinic which is a supplement containing iron > >> and B-12 among other things. Also giving her Vetri-DMG. She > >> initially had very bad diarrhea but I managed to clear this with > >> Metronidazole. She's also been dewormed and got Revolution. > >> Despite eating and showing an interest in food, she has been losing > >> weight (down to 5 lbs) so last week I had bloodwork done again. Here > >> are the results... > >> RBC - 3.79 M/ul (5.00-10.00) LOW > >> HCT - 14.8% (30.0-45.0) LOW > >> HGB 8.1 g/dl (9.0-15.1) LOW > >> MCV 39.2 fL (41.0-58.0) LOW > >> MCH - 21.4 pg (12.0-20.0) HIGH > >> MCHC - --- g/dL (29.0-37.5) > >> RDW - 21.7% (17.3-22.0) > >> %RETIC - 1.1% > >> RETIC - 40.7 K/uL (3.0-50.0) > >> WBC - 22.73. K/uL (5.50-19.50) HIGH > >> NEU - 18.48 K/uL (2.50-12.50) HIGH > >> PLT 698 K/uL (175-600) HIGH > >> Everything else was normal > >> My vet told me to start her on Clavamox since the white blood cell > >> count was high which is indicative on an infection somewhere. I was > >> really alarmed by the HCT number because I had a cat with chronic > >> renal failure and anemia some years back and I know that once the HCT > >> numbers get below 20% it can be very dangerous. With that cat, > >> Grayson, I used Aranesp very successfully to treat his anemia. He > >> eventually succumbed to the kidney failure but the Aranesp kept his > >> anemia at bay. > >> I've been reading that blood transfusions are one of the things to > >> do with Leuk+ cats once the HCT numbers get low but blood > >> transfusions in my area (South FL) are in the $1000 range and I > >> manage 6 colonies and have other cats at home with medical needs > >> including one that needs a full mouth extraction for stomatitis and I > >> just can't spend that type of money on Flaqui. > >> Do you guys think that Aranesp is something that would work on her? > >> She does not have kidney problems. However, based on the > >> reticulocyte levels, she does seem to have non-regenerative anaemia. > >> I read this document at Tanya's Comprehensive Guide to Feline Chronic > >> Kidney Disease that explains that the reticulocyte level needs to be > >> adjusted based on PCV... > >> In particular, since reticulocytes are commonly expressed in > >> percentage terms, they need to be adjusted to allow for the degree of > >> anaemia, i.e. 1% reticulocytes in a cat with a PCV of 20% is twice as > >> many as 1% reticulocytes in a cat with a PCV of 10%. > >> Let's assume your cat's PCV is 18% and the measured reticulocyte > >> count is 0.75%. You multiply the PCV by the measured count, then > >> divide the result by the normal PCV level (35% for many > >> laboratories). In this instance, you would get an adjusted result of > >> 0.39%, which indicates non-regeneration. > >> In contrast, if your cat's PCV was 13% and the measured reticulocyte > >> count was 0.75%, your adjusted result would be 0.28. This also > >> indicates non-regeneration, but it is more severe (i.e. the lower the > >> corrected value, the lower the regenerative response). > >> Flaqui's adjusted reticulocyte level is 14.8HCT X 1.1 RET = 16.28/35 > >> = .46 which indicates non-regeneration. > >> Any help would be appreciated. Flaqui has been doing better the > >> last couple of days. I think the Clavamox helped - but I really wish > >> I could improve those HCT numbers. > >> Maribel & Flaqui. > >> "The greatness of a nation can be judged by the way its animals are > >> treated." > >> -Mohandas Ghandi > >> > >> > >> _______________________________________________ > >> Felvtalk mailing list > >> Felvtalk@felineleukemia.org > >> > >> http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > >> _______________________________________________ > >> Felvtalk mailing list > >> Felvtalk@felineleukemia.org > >> > >> http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > > -------------- next part -------------- > > An HTML attachment was scrubbed... > > URL: > > ------------------------------ > > > > Subject: Digest Footer > > > > _______________________________________________ > > Felvtalk mailing list > > Felvtalk@felineleukemia.org > > http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > > > > > > ------------------------------ > > > > End of Felvtalk Digest, Vol 46, Issue 7 > > *************************************** > > > > _______________________________________________ > Felvtalk mailing list > Felvtalk@felineleukemia.org > http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org >
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