is re-encoding to UNCOMPRESSED VIDEO an option for you? 
No, because of file size.

Which pixelformat does the source video have? 
It varies, but most commonly 4:2:0 H.264 footage from Canon DSLR cameras.

Which editing tool are you using and which OS? 
My job involves processing camera footage to prepare it for editorial.  I work 
in OS X primarily with DaVinci Resolve and Premiere.  The editors usually use 
Avid MC, but it varies.  I use ffmpeg for a variety of little conversions 
depending on the situation.

In some cases, I can convert to a mezzanine codec like ProRes while conforming 
the frame rate, but sometimes the editor wants to work with the source material.
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