Yes. Guy and Gordon are correct - going with system default is probably the safest. Using custom fonts with international apps will require further testing.
There is Arial Unicode which is a Microsoft font, and is included with the default installation of Windows. OS X is different, somehow, but does include international fonts by default as well. I don't know about Linux systems. Alan >We have an app with multilingual support and we just use the default system font. >Don't some device fonts (e.g., Arial on Windows?) include glyphs for large portions of Unicode?