Yes it does, you can use plain HTTP/HTTPS GET & POST or Web Services. (Maybe some others, but that's all I looked at)
I end up using fine grained REST style Web Services which results in excellent performance and memory usage. I did find some problem returning multiple serialized unbounded complex types in Web Services using the Data Binding features of Flex, but got around them using Action Script. (And have much more reusable & maintainable code to boot)
