Thank you for your answer.

>PSpad isn't projected for such large files.
What a pity because it is hard too find a software able to open.
Even Notepad++ can't open large file.

>When you talk about: "It depends of file encoding."
What are you thinking about?
Do you think about ANSI or UTF8 encoding?

PSPad seems to take twice of memory than file size whatever encoding I choose in
option.

>> Also, I would like to know what is the aim of OpenFileSizeLimit=250000000 in
>> special settings?

>I'ts used for question if you really need to open big file
I have never see this question even in opening a big file.

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