Hi Doug, Thanks for the follow up. Do you recommend using a covariate such as mean thickness or is a covariate not necessary for cortical thickness analysis?
Thanks, Ajay On Thu, Sep 8, 2016 at 2:00 PM, Ajay Kurani <dr.ajay.kur...@gmail.com> wrote: > Hi Freesurfer Experts, > I am comparing a control group and 2 patient groups (HC vs Group1, HC > vs Group2, Group1 vs Group2). I am interested in seeing what is the most > appropriate covariate to use for both a cortical thickness analysis and LGI > analysis. I do not expect major changes in brain shape etc, and at most > maybe some more cortical atrophy in one of the groups) > > > I have seen several papers using ICV for cortical thickness analyses, > however I am not sure if this makes the most sense. Does ICV really scale > with thickness as a global measure to account for brain differences? To me > something like left mean thickness and right mean thickness may make more > sense, however, I am new to CT analyses and would like to get your feedback. > > Along with CT, I was interested in what covariate makes most sense in an > LGI analysis. Since LGI may change depending on the location within the > brain, does a global measure such as total surface area (or other measure) > make sense? Is there a suggested covariate to use for this type of > analysis? > > Are there any publications from your group regarind this issue? > > Thanks, > Ajay >
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