Hi John
why do you want to correct for them? They likely represent a pathological
process, so correcting for them may remove whatever effects you are looking
for, no? The space between the sulci and the ventricle volume won't
directly affect surface-based analysis, but of course the sulcal widening
likely reflects cortical atrophy that will be
cheers
Bruce
On Wed, 11 Jul 2018, John Anderson
wrote:
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Dear Freesurfer experts,
I have two groups of subjects (healthy and patients). The patients have
different degrees of
atrophy. Looking into the individual scans, the subjects are largely different
in the space between
the sulcuses and the size of ventricles. My questions are:
1. Is there any way to correct for these differences in the surface based
analysis?
2. Including eTIV covariate does it help in this case?
3. Does the resampling to "fsaverage" overcome the challenge of these
differences between the
subjects?
I appreciate any advice,
John
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