External Email - Use Caution        

group cc'd - thanks for the reminder.

My input data was the niftis. Example: recon-all -i 1kl5011.nii -subjid 
1kl5011 -all

Is there an efficient way to handle the flipped L-R or should I 
mri_convert the nifti and then do recon-all?

(Assuming that I can't just switch lh_ and rh_ in the aparcstats2table)

Ellen

On 9/15/2020 6:51 PM, Fischl, Bruce wrote:
> Hi Ellen
>
> Can you cc the list so that others can respond? What was your input data? Did 
> you not have dicoms?
>
> Cheers
> Bruce
>
> -----Original Message-----
> From: Ellen Ji <ellen...@bli.uzh.ch>
> Sent: Tuesday, September 15, 2020 12:38 PM
> To: Fischl, Bruce <bfis...@mgh.harvard.edu>
> Subject: Re: [Freesurfer] left-right flip?
>
>          External Email - Use Caution
>
> Hi Bruce,
>
> Unfortunately I just found the fiducial and realised that the L-R is 
> incorrect. Can I simply switch the lh_ and rh_ output from aparcstats2table 
> or do I need to run mri_convert on the nifti and run recon-all from the 
> beginning again?
>
> Thanks,
>
> Ellen
>
> On 9/15/2020 5:44 PM, Fischl, Bruce wrote:
>> And what is your input to recon-all? If it is dicom you should be
>> pretty confident that we will get it correct
>>
>> -----Original Message-----
>> From: freesurfer-boun...@nmr.mgh.harvard.edu
>> <freesurfer-boun...@nmr.mgh.harvard.edu> On Behalf Of Douglas N. Greve
>> Sent: Tuesday, September 15, 2020 10:17 AM
>> To: freesurfer@nmr.mgh.harvard.edu
>> Subject: Re: [Freesurfer] left-right flip?
>>
>> How are you checking the LR orientation?
>>
>> On 9/15/2020 4:10 AM, Ellen Ji wrote:
>>>            External Email - Use Caution
>>>
>>> Dear experts,
>>>
>>> I recently performed recon-all on a set of subjects and the output 
>>> (aparcstats2table and asegstats2table) will be part of a meta-analysis of 
>>> other labs' cohorts. When assessing the asymmetry index direction (relative 
>>> size of left vs right hemisphere across multiple rois), our dataset shows 
>>> an inversion of the mean asymmetry index in several structures compared to 
>>> the other cohorts.
>>>
>>> For example, in our dataset, the lateral ventricle volume is on
>>> average larger in the right hemisphere compared to the left, while the 
>>> opposite is true for all other cohorts. The same inversion of asymmetry is 
>>> visible in other structures that in general are more asymmetrical.
>>>
>>> In order to check this, I went through each T1 to make sure the orientation 
>>> was correct and indeed they are.
>>>
>>> Is there any possible way that there was a left-right inversion somewhere 
>>> during the recon-all pipeline? I want to make sure I did everything 
>>> correctly on our end and that the results are due to the biology and not a 
>>> technical mistake!
>>>
>>> I found this website on Left-right reversal, and it seems relevant to
>>> my issue, but I'm not fully understanding what this means (how would
>>> bias occur during segmentation?) -
>>> https://surfer.nmr.mgh.harvard.edu/fswiki/LeftRightReversal
>>>
>>> Many thanks for your input,
>>> Ellen
>>>
>>> ---
>>>
>>> Ellen Ji, PhD
>>> Postdoctoral Research Fellow
>>> Psychiatric University Hospital
>>> University of Zürich
>>> ellen...@bli.uzh.ch
>>> homanlab.github.io/ellen/
>>>
>>>
>>>
>>>
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>>> Freesurfer@nmr.mgh.harvard.edu
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