Please come today. For out-of-towners, here are the slides from Bill's
talk:
http://cnls.lanl.gov/q-bio/wiki/images/8/80/Hlavacek_2009.pdf
---------------
Systems Biology Introduction and Rule-based Modeling of Biochemical
Systems
SPEAKER: Bill Hlavacek, LANL Theoretical Biology and Biophysics, T-6
http://www.t6.lanl.gov/wish/
LOCATION: Wed, Oct 21, 10:30a-12:30p @ Santa Fe Complex, 624 Agua Fria
<http://www.sfcomplex.org>
ABSTRACT:
LANL researcher Bill Hlavacek hosts a WedTech talk on rule-based
modeling of biomechanical systems. This approach involves representing
molecules as structured objects (graphs) and molecular interactions as
(graph-rewriting) rules for transforming the attributes of these
objects.
The approach is notable in that it allows one to systematically
incorporate site-specific details about protein-protein interactions
into a model for the dynamics of a signal-transduction system, but the
method has other applications as well, such as following the fates of
individual carbon atoms in metabolic reactions. The consequences of
protein-protein interactions are difficult to specify and track with a
conventional modeling approach because of the large number of protein
phosphoforms and protein complexes that these interactions potentially
generate. In this tutorial talk, I will focus on how a rule-based
model is specified in the BioNetGen language (BNGL) and how a model
specification is analyzed using the BioNetGen software framework.
After Bill's talk, the wedt...@sfcomplex group will walk over to lunch
at El Tesoro at 12:30p
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