I've written up my experiences in a blog:

http://pvh.wp.sanbi.ac.za/2015/12/04/faster-galaxy-with-uwsgi/

The only Galaxy side changes were the ones mentioned on the Scaling page.
The Bad Gateway message means that Apache can't talk to the uWSGI so what
is the state of uWSGI?

Are you using supervisord? Does supervisorctl show the uWSGI process
running? Does ps ax |grep uwsgi show it running? What does sudo lsof -i
:4001 show is listening on port 4001? That would be the starting point of
my debugging.

Peter
On 4 Dec 2015 10:57, "Makis Ladoukakis" <makis4e...@hotmail.com> wrote:

> It is uwsgi that I am trying but with apache. Could you let me know what
> changes you made to the configuration of Galaxy?
>
> Thank you,
> Makis
>
> ------------------------------
> Date: Fri, 4 Dec 2015 10:01:56 +0200
> Subject: Re: [galaxy-dev] Multiple web servers and handlers Galaxy failed
> From: p...@sanbi.ac.za
> To: makis4e...@hotmail.com
> CC: galaxy-...@lists.bx.psu.edu; galaxy-dev@lists.galaxyproject.org
>
> Hi Makis, I recently implemented something like this using uWSGI with a
> nginx frontend. Would you consider using uWSGI instead of your current
> approach?
> On 4 Dec 2015 09:40, "Makis Ladoukakis" <makis4e...@hotmail.com> wrote:
>
> Sorry for bumping my own question but I didn't get any replies. Has anyone
> succesfully installed a production Galaxy instance?
>
> I could really use some advice.
>
> Thank you,
> Makis
>
> ------------------------------
> From: makis4e...@hotmail.com
> To: galaxy-...@lists.bx.psu.edu; galaxy-dev@lists.galaxyproject.org
> Date: Tue, 1 Dec 2015 18:03:44 +0200
> Subject: [galaxy-dev] Multiple web servers and handlers Galaxy failed
>
> Hello everyone,
>
> I am trying to setup a Galaxy instance for a multi-user production
> environment and I tried to follow the instructions here:
>
> https://wiki.galaxyproject.org/Admin/Config/Performance/Scaling
> https://wiki.galaxyproject.org/Admin/Config/Performance/ProductionServer
> https://wiki.galaxyproject.org/Admin/Config/ApacheProxy
>
> but when I tried to start my galaxy instance (GALAXY_RUN_ALL=1 sh run.sh
> --daemon) I got the following error in my browser:Bad Gateway The proxy
> server received an invalid response from an upstream server.
>
>
> I don't get any errors from the paster.log files so I am guessing the
> error is somewhere in my apache configuration although I can't see where it
> could be.
>
>
> Has anyone encountered this problem before?
>
> Kind regards,
> Makis
>
>
> P.S. My apache configuration is as follows:
>
> I added that to my apache httpd.conf file:
>
> #for galaxy
>     #RewriteRule ^/galaxy(.*) http://localhost:8091$1 [P]
>     RewriteRule ^/galaxy$ /galaxy/ [R]
>     RewriteRule ^/galaxy/static/style/(.*)
> /home/galaxy/galaxy/static/june_2007_style/blue/$1 [L]
>     RewriteRule ^/galaxy/static/scripts/(.*)
> /home/galaxy/galaxy/static/scripts/packed/$1 [L]
>     RewriteRule ^/galaxy/static/(.*) /home/galaxy/galaxy/static/$1 [L]
>     RewriteRule ^/galaxy/favicon.ico
> /home/galaxy/galaxy/static/favicon.ico [L]
>     RewriteRule ^/galaxy/robots.txt /home/galaxy/galaxy/static/robots.txt
> [L]
>
>     LoadModule uwsgi_module /etc/httpd/modules/mod_uwsgi.so
>
>     <Location "/galaxy">
>     Sethandler uwsgi-handler
>     uWSGISocket 127.0.0.1:4001
>     uWSGImaxVars 512
>     </Location>
>
> I am also attaching my job_conf.xml and galaxy.ini file.
>
>
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