https://gcc.gnu.org/bugzilla/show_bug.cgi?id=103882
--- Comment #10 from Jakub Jelinek <jakub at gcc dot gnu.org> --- That is just a total misunderstanding why the compiler needs to know (be told) the observable side-effects of the inline asm. Interprocedural optimizations are just one of the many reasons, much more important is that it needs to know what the inline asm does for code generation within the function, it needs to know in which registers or memory it can spill values live across the inline asm etc. Don't use inline asm if you are unable or not willing to tell the compiler how it behaves.